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Deoxyadenosine in aplication of preparing bypolipidemic

A blood lipid-lowering drug, deoxyadenosine technology, applied in the application field of 3'-deoxyadenosine in the preparation of drugs for lowering serum triglycerides, can solve problems such as gastrointestinal dysfunction, toxic side effects, etc.

Inactive Publication Date: 2004-10-27
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But it also has many side effects, such as: about 2%-3% of patients after taking the drug, gastrointestinal dysfunction, nausea, insomnia, muscle tenderness and rash

Method used

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  • Deoxyadenosine in aplication of preparing bypolipidemic
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  • Deoxyadenosine in aplication of preparing bypolipidemic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Example 1: Effect of 3'-deoxyadenosine prophylactic administration on blood lipid content of hyperlipidemia model mice

[0056] Materials and Methods

[0057] [Experimental animals] Kunming mice, male, weighing 18-20 g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army, license number: SCXK (Army) 2002-001.

[0058] [Test product] 3'-deoxyadenosine (isolated from the fruiting body of Cordyceps militaris, the analyzed purity is above 99.9%).

[0059] [Feed] Basic feed and high-fat feed were provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, license number: Jingdong Xuzi 003, certificate number: 0015790. Basic feed formula: 20% flour, 10% rice flour, 20% corn, 20% soybean flour, 25% bran, 2% bone meal, 2% fish meal. High-fat feed formula: 79% basic feed, 10% lard, 10% egg yolk powder, 1% cholesterol.

[0060] [Positive drug] Fe...

Embodiment 2

[0090] Example 2: Effect of 3'-deoxyadenosine preventive administration on blood triglyceride content in hyperlipidemia model rats

[0091] Materials and methods

[0092] [Experimental animals] Wistar rats, male, weighing about 220±20 g, were purchased from the Institute of Experimental Animals, Chinese Academy of Medical Sciences, license number: SCXK-11-00-0006.

[0093] [Test product] 3'-deoxyadenosine (isolated from the fruiting body of Cordyceps militaris, the analyzed purity is above 99.9%).

[0094] [Feed] Basic feed and high-fat feed were provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, license number: Jingdong Xuzi 003, certificate number: 0015790. Basic feed formula: 20% flour, 10% rice flour, 20% corn, 20% soybean flour, 25% bran, 2% bone meal, 2% fish meal. High-fat feed formula: 79% basic feed, 10% lard, 10% egg yolk powder, 1% cholesterol.

[0095] [Positive drug] Fenofibrate (Lipingzhi), French Lib...

Embodiment 3

[0137] Example 3 3'-deoxyadenosine acute toxicity test

[0138] Materials and methods

[0139] [Experimental animals] Kunming mice, weighing 18-22g, half male and half male, provided by the Department of Experimental Animal Science, Peking University Health Science Center, certificate number 01-3049

[0140] [Test product] 3'-deoxyadenosine (is isolated from the fruiting body of Cordyceps militaris for this laboratory, see embodiment 1).

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Abstract

An application of 3'-deoxyadenosine in preparing the medicine for decreasing blood fat, especially the serum triglyceride, is disclosed.

Description

technical field [0001] The invention relates to the application of 3'-deoxyadenosine in the preparation of blood lipid-lowering drugs, in particular to the application of 3'-deoxyadenosine in the preparation of serum triglyceride-lowering drugs. Background technique [0002] Blood lipid is the general term for the lipids contained in the blood. Lipids in blood mainly include triglycerides, phospholipids, cholesterol and free fatty acids. The lipid content in the blood accounts for only a very small part compared with the total body lipid, but it is transported between various tissues and can often reflect the lipid metabolism in the body. Normal adult plasma lipid content is relatively stable, with a certain fluctuation range. Lipid levels are also susceptible to non-disease factors, including those caused by diet or short-term starvation. But this effect is only temporary and can return to normal conditions. However, if one or more lipids in the plasma are continuously ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7076A61P1/16A61P1/18A61P3/06A61P3/10A61P27/02
Inventor 朱平朱海波朱慧新张岭何惠霞王全程克棣石建功杨永春
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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