Tissue engineering compound material for repairing nerve injury and its preparation

A nerve injury and repair material technology, applied in medical science, surgery, etc., can solve the problems of unfavorable regenerative fiber directional growth, irregularity, and effect, etc., to improve mechanical properties, reduce decomposition speed, increase tensile strength and The effect of stiffness

Inactive Publication Date: 2004-11-17
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the internal structure of the previous composite bridging carrier materials has no certain rules (in terms of pore size and direction), it is not conducive to the directional growth of regeneration fibers in spinal cord or peripheral nerve segmental injuries, thus affecting the effect of treatment or experiments.
There is no similar report in the world to prepare collagen bridging materials with longitudinal and axial pore diameters. The material we developed has the advantages of uniform internal pore size under the same conditions and pores parallel—completely parallel to the axial direction.

Method used

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  • Tissue engineering compound material for repairing nerve injury and its preparation
  • Tissue engineering compound material for repairing nerve injury and its preparation
  • Tissue engineering compound material for repairing nerve injury and its preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Example 1 (according to the ratio of type I collagen: IV collagen: heparan sulfate: gelatin is 2300: 50: 1: 1150):

[0035] According to the technical scheme of the present invention, taking collagen, gelatin and heparan sulfate as examples, its preparation method is carried out according to the following steps:

[0036] 1. Weigh a certain amount of type I collagen according to the ratio and dissolve it in 0.05M acetic acid solution for 24 hours at a concentration of 27.5mg / ml;

[0037] 2. In a constant temperature environment at 4°C, stir at 18000r / min for 90min to make a suspension;

[0038] 3. In addition, weigh a certain amount of heparan sulfate and type IV collagen according to the ratio and add them to 0.05M acetic acid solution to dissolve for 24 hours;

[0039] 4. At a constant temperature of 4°C, stir at 18000r / min for 90min to make a suspension;

[0040]5. Mix the two suspensions and keep the temperature at 4°C, stir at 18,000 r / min for 90 minutes to make a...

Embodiment 2

[0049] Embodiment 2: adopt collagen (type I), heparan sulfate and gelatin as raw material, its weight is respectively 1150mg, 0.5mg, 575mg, implementation process is the same as example 1;

Embodiment 3

[0050] Embodiment 3: adopt collagen (type I, type IV) and gelatin as raw material, its weight is respectively 1150mg, 25mg, 575mg, implementation process is the same as example 1;

[0051] Embodiment 3: adopt collagen (type I) and heparan sulfate as raw material, its weight is respectively 1150mg, 0.5mg, implementation process is the same as example 1;

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Abstract

The invention discloses a complex type tissue engineering nerve damage renovation material, which comprises type I collagen, heparitin sulfate, type IV collagen and gelatin. The material has simple adjusting inner diameter and uniform single orientation axial bore, it is easy to be made into different external forms, e.g. cylinder or rectangle.

Description

technical field [0001] The present invention aims to develop a bridge for repairing central and peripheral nerve injuries with good biocompatibility and biodegradability, involving various biological raw materials such as collagen, gelatin and aminoglycans, as well as their processing technology and production method . The material can be used not only for basic research on nerve injury repair, but also for clinical bridging repair after segmental injury and defect of human spinal cord and peripheral nerve. Background technique [0002] The extracellular matrix (ECM) is the basis for cells to survive and maintain cell functions and biological characteristics. It is the basic carrier of life and provides organisms with scaffolds for maintaining structures and places for biological functions. The functions of ECM, such as cell adhesion, intercellular signal transmission, and migration, are unique and unavailable to other substances, and have a profound impact on the functions...

Claims

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Application Information

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IPC IPC(8): A61L31/04
Inventor 罗卓荆梁伟王树森
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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