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Quasi-phase matching photodynamic therapeutic and diagnostic laser light source

A technology of photodynamic therapy and quasi-phase matching, which is applied in the directions of diagnosis, treatment, and lasers, and can solve problems such as inability to adjust wavelength, clamping of wavelength tunability, and low probability

Inactive Publication Date: 2004-11-24
APPLIED BIOPHOTONIC
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  • Abstract
  • Description
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Problems solved by technology

However, the tunability of the wavelength emitted by semiconductor lasers is limited by the limitations of material properties, and large wavelength adjustments cannot be made. Therefore, the probability of the emitted wavelength being exactly the specific absorber of the photosensitizer is naturally low.
In addition, because the laser emitting area of ​​the semiconductor laser is very small, the problem of heat dissipation becomes more serious when it operates at high power

Method used

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  • Quasi-phase matching photodynamic therapeutic and diagnostic laser light source
  • Quasi-phase matching photodynamic therapeutic and diagnostic laser light source
  • Quasi-phase matching photodynamic therapeutic and diagnostic laser light source

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Embodiment Construction

[0115] The photodynamic therapy and diagnostic laser system device disclosed by the present invention is as follows figure 1 As shown, at least a laser system 2 , a lens coupling system 8 and an optical transmission output device 10 , 12 are included. The laser system 2 is composed of a pump laser 4 , a coupling lens 5 and a wavelength converter 6 . The wavelength converter 6 is used to convert the specific wavelength emitted by the pump light 4 to at least one wavelength of laser light suitable for photodynamic therapy (PDT) or diagnosis (PDD). The laser light generated by the conversion is then effectively focused into the optical fiber 10 of the optical transmission output device through the lens coupling system 8 and transmitted to the optical pen system 12 of the optical transmission output device for proper focusing and output to a specific target point, such as Tumor tissue with photosensitizing drugs. The photodynamic therapy and diagnostic laser system device can al...

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Abstract

The present invention relates to a laser system equipment, in particular, it is a laser light source for medical photodynamic therapy and diagnosis. Said laser system equipment includes a laser pump source which can emit at least a specific laser light wavelength for wavelength converter in the pump-laser resonant cavity system; a wavelength converter which uses a quasi-phase-matched technique to convert said specific laser light wavelength into at least one laser light wavelength applicable to photodynamic therapy and diagnosis; a laser resonant cavity system, said wavelength converter is placed in its cavity interior and used for increasing laser light intensity output; and an optical transmission output device for receiving and transmitting laser light outputted by said laser resonant cavity system.

Description

(1) Technical field [0001] The invention relates to a laser system device, especially a laser light source suitable for medical photodynamic therapy (Photodynamic Therapy; PDT) and diagnosis (photodynamic diagnosis; PDD). (2) Background technology [0002] Malignant tumors have become the leading cause of death among Chinese people. Accurate diagnosis and timely treatment of early malignant tumors are the prerequisites for good prognosis. In the diagnosis of malignant tumors, the fluorescence diagnostic method with the addition of fluorescent dyes as photosensitizers provides quite reliable diagnostic results. This method is known as photodynamic diagnosis (PDD) method. Commonly used photosensitizers, such as hematoporphyrinderivative (HpDs) and prodrug 5-aminolevulinic acid (ALA) for hem-biosynthesis, are harmful to tissue blood vessels and Metabolic proliferative activity is very sensitive, allowing them to have a high accumulation and residence time in tumor tissue. S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/00A61B18/20A61N5/067G02F1/35H01S3/00
Inventor 黄衍介林彦颖陈进庭
Owner APPLIED BIOPHOTONIC
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