Clearing heat and detoxicating medicine
A heat-clearing and detoxifying technology, applied in the direction of antipyretics, drug combinations, pharmaceutical formulas, etc., can solve the problems of slow disintegration, slow onset of effect, complicated process, etc., and achieve short disintegration time, convenient administration, and simple process Effect
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Embodiment 1
[0014] Combine andrographis paniculata, gardenia, and Ophiopogon japonicus in the prescription, use ethyl acetate as a solvent, carry out reflux extraction, collect the extract, recycle ethyl acetate to obtain a concentrated extract (relative density 1.1, measured at 60 ° C), according to Extract: The weight ratio of the dropping pill base is 1:2.5, the concentrated extract is added to the molten dropping pill base polyethylene glycol 4000, mixed evenly, and made by dropping under the condition of maintaining a constant temperature of 80±2°C Dropping pills are obtained after cooling and drying.
Embodiment 2
[0016] Combine the Andrographis paniculata and Fructus Gardeniae in the prescription, carry out percolation extraction with 70% ethanol, collect the extract, reclaim the ethanol, and obtain the concentrated extract of Andrographis paniculata and Fructus Gardeniae (relative density 1.06, measured at 60°C); The Ophiopogon japonicus is extracted by decocting with water and liquid, the extract is concentrated to a relative density of 1.25 (measured at 60°C), the above extracts are combined, and the concentrated extract is added to the molten In the dropping pill matrix polyethylene glycol 6000 in the state, mix evenly, drop to make dropping pills under the condition of maintaining a constant temperature of 80±2°C, cool and dry.
Embodiment 3
[0018] The Andrographis paniculata in the prescription are reflux extracted with 85% ethanol, the extract is collected, and the ethanol is reclaimed to obtain the concentrated extract of Andrographis paniculata (relative density 1.15, measured at 60°C); the gardenia and Radix Ophiopogon japonicus in the prescription are combined and decocted with water Extract by boiling, concentrate the extract to a relative density of 1.20 (measured at 60° C.), combine the above extracts, and add the concentrated extract to the dripping pill matrix in a molten state according to the weight ratio of extract: dripping pill matrix 1:2. In ethylene glycol 4000, mix evenly, drop into drop pills under the condition of maintaining a constant temperature of 80±2°C, cool and dry.
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