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Fibrauretine capsule tablet and its preparation method

A kind of technology of patinarin and coated tablets, which is applied in the field of process innovation of fenugreek preparations, can solve the problems of lack of medical compliance, less clinical application, less indications, etc., so as to overcome the inconvenience of medication, reduce adverse reactions, Avoid unacceptable effects

Inactive Publication Date: 2004-12-29
黄羿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Over the years, from the perspective of the clinical use of palmatine preparations, due to the inconvenience of use and few indications of palmatine suppositories, the amount of clinical application is very small; the presence of palmatine injections is inconvenient to carry and administer; Tablets) due to the lack of medical compliance due to the extremely bitter taste, many patients have difficulty in swallowing and give up treatment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, select the following main and auxiliary material components by weight ratio: 50% palmatine, 45% starch, 4% sodium carboxymethyl starch, an appropriate amount of 5% hypromellose solution, 1% magnesium stearate , according to the wet granulation tabletting method to make the padatine coated tablet core of the present invention, that is, take padatine and pharmaceutical excipients according to the above weight ratio, add an appropriate amount of wetting agent or adhesive, stir evenly and Made into soft materials, granulated, granulated after drying, mixed with a lubricant, and compressed into tablets; the above-mentioned tablet core is made into a coating film on the outside of the tablet core by the coating method described in the present invention. The above-mentioned palmatine-coated tablets.

Embodiment 2

[0017] Embodiment 2, select the following main and auxiliary material components by weight ratio, 25% palmatine, 70% starch, 4% sodium carboxymethyl starch, an appropriate amount of 5% hypromellose solution, 1% magnesium stearate , according to the wet granulation tabletting method to make the padatine coated tablet core of the present invention, that is, take padatine and pharmaceutical excipients according to the above weight ratio, add an appropriate amount of wetting agent or adhesive, stir evenly and Made into soft materials, granulated, granulated after drying, mixed with a lubricant, and compressed into tablets; the above-mentioned tablet core is made into a coating film on the outside of the tablet core by the coating method described in the present invention. The above-mentioned palmatine-coated tablets.

Embodiment 3

[0018] Example 3, the following main and auxiliary material components are selected according to the weight ratio: 75% patellogenin, 20% microcrystalline cellulose, 4% sodium carboxymethyl starch, an appropriate amount of 5% hypromellose solution, 1% hard Magnesium fatty acid, according to the wet granulation tabletting method, make the palmatine-coated tablet core of the present invention, promptly take palmetine and pharmaceutical adjuvant according to the above weight ratio, add an appropriate amount of wetting agent or binding agent, Stir evenly and make a soft material, granulate, granulate after drying, add a lubricant, mix evenly, and compress the tablet; after the above-mentioned tablet core is made into a coating film on the outside of the tablet core by the coating method described in the present invention The palmatine-coated tablet described in the present invention.

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PUM

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Abstract

The fibrauretine coating tablet is prepared with fibrauretine as active component, and through mixing with at least one kind of supplementary material including stuffing, wetting agent, adhesive, disintegrating agent and lubricant; pelletizing, drying and tabletting core; and covering the core with coating film to form the coating tablet. The coating tablet may be sugar-coated tablet, film coated tablet or enteric coated tablet. After being orally taken, the fibrauretine coating tablet is leached and absorbed in gastrointestinal tract and has no bitter tasted and no irritation to stomach. Each tablet contains fibrauretine in 10-1000 mg.

Description

technical field [0001] The invention relates to a process innovation of a palmatine preparation, in particular to a palmetine-coated tablet and a preparation method thereof. Background technique [0002] Fibrauretnum (Fibrauretnum) is an alkaloid extracted from the stem of the plant Fibraurea recisn Pierre, with the molecular formula C 22 h 22 o 4 HCl·3H 2 O, yellow needle-like crystal, melting point 198-201°C, extremely bitter taste, odorless. Soluble in hot water, slightly soluble in water, slightly soluble in ethanol and chloroform, almost insoluble in ether. This product has a strong inhibitory effect on mold, staphylococcus, gonorrhoeae, mycoplasma chlamydia, and acid-resistant analyte bacillus. Inflammation and other diseases have received good results, and no toxic side effects have been found. [0003] Huangtengsu has been included in the 1977 edition of the "Chinese Pharmacopoeia", and Huangtengsu tablets (plain tablets), Huangtengsu suppository and Huangtengs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/4745A61P1/12A61P11/00A61P13/02A61P15/00A61P27/02A61P29/00A61P31/04
Inventor 黄羿
Owner 黄羿
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