Chinese medicinal preparation for treating coronary heart disease and angina pectoris and its preparing process

A technology of coronary heart disease angina pectoris and traditional Chinese medicine preparations, which is applied in the field of traditional Chinese medicine preparations for treating coronary heart disease angina pectoris and its preparation, and can solve the problems of many ineffective ingredients remaining and large doses taken by patients

Inactive Publication Date: 2004-12-29
张正生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention is derived from Shuxiong Tablets in the Pharmacopoeia of the People's Republic of China (1st edition in 2000). Shuxiong Tablets has certain curative effect on coronary heart disease angina pectoris, but because it is a tablet, it needs to be disintegrated in the stomach and absorbed in the intestines. For a certain period of time, the time to reach the blood drug concentration (drug effect) will be longer. Therefore, it has a great disadvantage for emergencies such as coronary heart disease and angina pectoris. Shuxiong tablets are based on the traditional process of water extraction and alcohol precipitation, adding certain excipients Made, many ineffective ingredients are retained, and patients take a large amount

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take 100 grams of Panax notoginseng decoction pieces and grind them through a 10-mesh sieve, take the pulverized Panax notoginseng, add 5 times the amount (W / V) of ethanol (60%) to soak for 0.5 hours, and extract with an ultrasonic extraction tank for 20 minutes , the ultrasonic power is 100W, the stirring speed is 50RPM, the temperature is controlled at room temperature, after extraction, it is filtered, the filtrate is recovered to ethanol, concentrated, dried and pulverized, the powder is mixed with a certain amount of resin, and the macroporous adsorption resin (D101 type) is applied. , eluted with 20% ethanol until complete, recovered ethanol to the utmost, concentrated, dried and crushed, weighed 12.080 grams, and set aside; take 200 grams of Chuanxiong decoction pieces and crush them, pass through a 10-mesh sieve, take the crushed Chuanxiong, add 5 times the amount The ethanol (60%) of (W / V) soaks 0.5 hour, extracts with ultrasonic extraction tank, and the time is...

Embodiment 2

[0052] Take notoginseng decoction pieces and crush 100 grams, pass through a 15-mesh sieve, take the crushed notoginseng, add 8 times the amount (W / V) of ethanol (80%) to soak for 1 hour, and extract with an ultrasonic extraction tank for 50 minutes , the ultrasonic power is 5400W, the stirring speed is 1500RPM, and the control temperature is 55°C. After extraction, it is filtered, and the filtrate is recovered from ethanol until it is concentrated, dried and crushed. ), eluted completely with 60% ethanol, recovered ethanol to the utmost, concentrated, dried and crushed, weighed 12.080 grams, and set aside; take 200 grams of Chuanxiong decoction pieces and pulverize them, pass through a 15-mesh sieve, take the pulverized Chuanxiong, add 8 times The amount (W / V) of ethanol (80%) was soaked for 1 hour, extracted with an ultrasonic extraction tank, and the time was 50 minutes, the ultrasonic power was 5400W, the stirring speed was 1500RPM, and the control temperature was 55 ° C. A...

Embodiment 3

[0054] Take 100 grams of Panax notoginseng decoction pieces and crush them, pass through a 12-mesh sieve, take the crushed Panax notoginseng, add 6 times the amount (W / V) of ethanol (70%) to soak for 0.7 hours, and extract with an ultrasonic extraction tank for 35 minutes , the ultrasonic power is 1900W, the stirring speed is 1000RPM, and the temperature is controlled at 40°C. After extraction, it is filtered, and the filtrate is recovered from ethanol until it is concentrated and dried. ), eluted with 50% ethanol until complete, recovered ethanol to the utmost, concentrated, dried and crushed, weighed 12.080 grams, and set aside; take 200 grams of Chuanxiong decoction pieces and pulverize them, pass through a 13-mesh sieve, take the pulverized Chuanxiong, add 6 times The ethanol (75%) of amount (W / V) is soaked 0.8 hour, carries out extraction with ultrasonic extraction tank, and the time is 30 minutes, and ultrasonic power is 3000W, and stirring speed is 900RPM, and control te...

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PUM

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Abstract

The Chinese medicine preparation for treating coronary heart disease and angina pectoris consists of the effective parts of notoginseng and Chuanxiong rhizome obtained through ultrasonic extraction and macroporous resin adsorption and purification and the effective parts of safflower obtained through acid water extraction and macroporous resin adsorption and purification. The Chinese medicine preparation is prepared in medicine powder for injection, dripping pill or soft capsule. Pharmacological experiment shows that the preparation can improve the syndromes of dog with acute myocardial ischemia and myocardial infarction obviously, dilate coronary artery obviously, reduce the resistance of coronary artery, reduce myocardial damage and lower the content of serum creaatine phosphate kinase. The present invention has fast and obvious treating effect.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a traditional Chinese medicine preparation for treating coronary heart disease angina pectoris and a preparation method thereof. Background technique [0002] Coronary heart disease angina pectoris is one of the major human diseases, and its mortality rate has always been the first among many major diseases. Coronary heart disease angina pectoris is a common disease in internal medicine, and it mainly occurs in middle-aged and elderly patients. It tends to be younger, therefore, the incidence rate of coronary heart disease tends to increase, and the task of prevention and treatment is very heavy, which has attracted attention both at home and abroad. With the development of modern science and technology, people have also made some progress in the diagnosis and prevention of coronary heart disease. , The application of electron beam CT machine, bio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/20A61P9/10
Inventor 张正生
Owner 张正生
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