Soybean aglycone soft capsule and its preparing method

A technology of daidzein and soft capsule, applied in the field of medicine, can solve problems such as poor bioavailability, and achieve the effects of convenient administration, increased permeability, and improved bioavailability

Inactive Publication Date: 2005-01-12
邵爱霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are only tablets and capsules for its oral preparations clinically. Because this product is a poorly soluble substance, neither soluble in water nor soluble in fat substances, it is difficult for ordinary tablets and capsules to change its poor bioavailability. question

Method used

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  • Soybean aglycone soft capsule and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Component Quantity (g / grain)

[0043] Daidzein 0.4

[0044] Povidone 2

[0045] Propylene glycol 3.96

[0046] Methylcellulose 0.034

[0047] Polysorbate 60 0.096

[0048] Gelatin 4.58

[0049] Glycerin 1.692

[0050]Methyl sorbate 0.00448

[0051] Red iron oxide 0.5834

[0052] water 3.65

[0053] The preparation method is as follows:

[0054] (1) Put gelatin and glycerin in a glue tank and add purified water. The temperature of the glue tank is 75°C. After melting, add opacifying agent and preservative, stir evenly, vacuumize and degas, keep warm and stand for use.

[0055] (2) Add the main drug daidzein into a co-solvent, an emulsifier, and a disintegrant to dissolve in the diluent, stir evenly, and let stand at room temperature.

[0056] (3) Pour the prepared medicinal solution into the pill making machine, finalize the shape, dry in a drying room, and plan to get it.

Embodiment 2

[0058] Component Quantity (g / grain)

[0059] Daidzein 0.25

[0060] polyethylene glycol 8000 1.35

[0061] Beeswax 0.035

[0062] Polypropylene glycol 0.012

[0063] Gelatin 2.78

[0064] Glycerin 1.22

[0065] Clove oil 0.0038

[0066] Titanium dioxide 0.0384

[0067] water 2.5

Embodiment 3

[0069] Component Quantity (g / grain)

[0070] Daidzein 0.045

[0071] Polysorbate 40 0.225

[0072] Mineral oil 0.4455

[0073] Trihydroxymethane 0.0045

[0074] Alginic acid 0.0028

[0075] Gelatin 0.504

[0076] Glycerin 0.2076

[0077] Benzoic acid 0.000504

[0078] Barium sulfate 0.0623

[0079] water 0.54

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Abstract

A soybean aglycone softgel is composed of the liquid medicine prepared from soybean aglycone, cosolvent, diluent, emulsifierand disintegrant and the shell prepared from gelatin, glycerine, opacifier and antiseptic.

Description

(1) Technical field [0001] The invention relates to a soft capsule oral medicine containing an effective dose of daidzein and a preparation method thereof, belonging to the technical field of medicine. (two) background technology: [0002] Daidzein is one of the main active ingredients of kudzu root, which can expand coronary arteries, relieve vasospasm, improve normal ischemic myocardial metabolism, slowly reduce heart rate, reduce myocardial oxygen consumption, improve myocardial function, reduce TXA2 / PGI2, and reduce blood viscosity It can resist isoproterenol, reduce capillary spasm, improve microcirculation, and this product also has estrogen-like effects, which can obviously improve and eliminate the symptoms of menopause in women. Oral administration is suitable for cardiovascular and cerebrovascular diseases, including hypertension and symptomatic hypertension, coronary heart disease, angina pectoris, myocardial infarction, cerebral thrombosis, arrhythmia, vertigo, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/352A61P1/08A61P9/02A61P9/06A61P9/10A61P9/12A61P15/12
Inventor 邵爱霞蔡杏娟杨倩陈祝功杨秀梅孙际旋王庆莹
Owner 邵爱霞
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