Preparation process for ginsenoside Rg1

A technology of ginsenoside and preparation process, which is applied in the field of preparation of ginsenoside monomer

Inactive Publication Date: 2005-01-19
云南特安呐制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ginsenoside Rg 1 The preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] Take 1.2kg of panax notoginseng saponins and dissolve them with 30% ethanol. The solution is adsorbed by 30kg of pretreated D-101 macroporous resin. Then the resin column is washed with 30% ethanol to wash off the ginsenosides, followed by 60- Rinse the resin column with 80% ethanol, wash off the ginsenoside saponins, and then evaporate the dilute alcohol solution of ginsengtriol saponins under reduced pressure to obtain about 650 g of ginsengtriol saponins.

[0016] Weigh 200g of ginsengtriol-type saponins, dissolve them by heating with 95% ethanol as little as possible, adsorb on 300g of 80-100 mesh silica gel, and dry under 60°C. Weigh 6kg of 200-300 mesh silica gel and pack it on the column, and install the above crude silica gel adsorbing 200g of triol saponins on the upper part of the 200-300 mesh silica gel column, and carry out low pressure 0.5kg / cm 2 Dry column chromatography, eluted with chloroform-methanol-water (7:3:1) lower solvent system, collect 500ml for eac...

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PUM

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Abstract

The invention relates to a preparation process for panaxoside monomer comprising the steps of, (1) dissolving total notoginseng saponin with alcohol, (2) passing through pretreated big hole resin columns, washing panaxatriol saponin with alcohol, rinsing the resin columns, (3) reclaiming alcohol through decompression, spray drying, obtaining panaxadiol saponin, (4) adsorbing on chromatographic silica gel, drying, (5) proceeding low pressure chromatography, (6) reclaiming solvent, vacuum drying to obtain the panaxoside Rg1 crude product, (7) proceeding step 4, 5 and 6 to obtain refined Rg1.

Description

Technical field [0001] The invention relates to a preparation process of ginsenoside monomers. Background technique [0002] Chinese patent application CN1293198A (application number 00123074.3) discloses a "preparation method of rare ginsenosides", which is to dissolve alkali metal hydroxides in high-boiling fatty alcohol compounds, the concentration of which is generally 0.5%-50%, preferably The concentration is 3-15. Continue heating while stirring for alkaline hydrolysis. The hydrolysis temperature is 180℃-270℃, preferably 190-220℃. After the reaction is completed, cool to room temperature and dilute with water. Extract by organic solvent or large pore adsorption resin The product of the invention is obtained by adsorption. Ginsenoside Rg 1 The preparation process has not yet been reported. Summary of the invention [0003] The purpose of the present invention is to provide a ginsenoside Rg 1 The preparation process. [0004] Ginsenoside Rg of the present invention 1 The pre...

Claims

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Application Information

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IPC IPC(8): C07J63/00
Inventor 唐修文
Owner 云南特安呐制药股份有限公司
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