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Prescription of liquid status of Vitamin K1 and its preparation

A vitamin and liquid type technology, applied in the field of medicine, can solve the problems of low drug absorption, slow onset of effect, and unsuitable application for diabetic patients, and achieves the effect of small individual differences in curative effect, fast absorption, and beneficial clinical treatment.

Inactive Publication Date: 2005-03-16
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Vitamin K Supplement 1 The best way is oral administration, the existing oral dosage form is tablet, because vitamin K 1 It is oily, and it is difficult to prepare tablets. There are problems such as oil leakage and complicated procedures. At the same time, due to vitamin K 1 Insoluble in water, the drug in the tablet has little absorption in the body and fluctuates greatly
In addition, existing vitamin K 1 Tablets are sugar-coated tablets with slow disintegration and slow onset of action, and are not suitable for diabetic patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Component Weight (mg)

[0024] Vitamin K 1 5

[0025] soybean oil 150

[0026] Preparation Process:

[0027] Weigh the vitamin K1 and soybean oil in the prescribed amount, put them in the batching tank, stir and mix to obtain the vitamin K1 liquid. The obtained liquid can be prepared into soft capsules, liquid hard capsules and drops.

Embodiment 2

[0029] Component Weight (mg)

[0030] Vitamin K 1 2

[0031] soybean oil 100

[0032] Span 80 10

[0033] Alpha-Tocopherol 1

[0034] Preparation Process:

[0035] Weigh the prescribed amount of Span 80, α-tocopherol and soybean oil, put them in the batching tank, mix well and dissolve, add vitamin K1, stir and mix well to obtain vitamin K1 liquid. The obtained liquid can be prepared into soft capsules, liquid hard capsules and drops.

Embodiment 3

[0037] Component Weight (mg)

[0038] Vitamin K 1 5

[0039] Peanut Oil 200

[0040] beeswax 5

[0041] Dibutylhydroxytoluene 1

[0042] Preparation Process:

[0043] Weigh the prescribed amount of beeswax, dibutyl hydroxytoluene and peanut oil, put them in the batching tank, mix well, heat and dissolve, add vitamin K1, stir and mix to obtain vitamin K1 liquid. The obtained liquid can be prepared into soft capsules, liquid hard capsules and drops.

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PUM

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Abstract

The invention discloses a liquid type composition of vitamin K1 and its preparation and method for making same, wherein the composition comprises vitamin K1 and solvent, the liquid type vitamin K1 can be prepared into the dosage forms of capsule, liquid type hard gelatin capsule and drop. The preparation process is also disclosed by the invention.

Description

Technical field: [0001] The present invention relates to the technical field of medicine, it is exactly a kind of vitamin K 1 Liquid formula and preparation thereof. Background technique: [0002] Vitamin K 1 , its chemical name is: 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione. This product is a vitamin drug, which is necessary for the liver to synthesize factors □, □, □, □. Vitamin K deficiency can cause disorders or abnormalities in the synthesis of these coagulation factors, and clinical bleeding tendency and prolonged prothrombin time can be seen. Vitamin K is closely related to blood coagulation. When it is deficient, it can cause the liver to inhibit the synthesis of various coagulation factors, prolong the coagulation time of the body and cause bleeding tendency. Timely supplementation of vitamin K can restore the coagulation function. Vitamin K 1 It also has direct liver-protecting and anti-inflammatory effects. It can lower the bilirubi...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/122A61P1/16A61P7/04
Inventor 邓意辉吴琼
Owner SHENYANG PHARMA UNIVERSITY
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