Effective extract of Chinese silkuine bark with cardotonic function and its preparing process and uasge

A technology of saponin and its extract, which is applied in the field of medicine, can solve the problems of low extraction efficiency of salivatoxin, inability to effectively control the content of salivatoxin, and lack of enrichment of salivatoxin, etc., so as to achieve convenient Quality control, low cost, good enrichment effect

Active Publication Date: 2005-03-16
TIANJIN TASLY PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cardiac glucosinolates in Persica radiata were not enriched; and the content of basilicates could not be effectively controlled
[0003] Japanese scholar Seiichi Sakama (Seiichi Sakama, et al.Constituents of Chinese Crude Drug "Wujiapi" I.Studies on the Aglycones of Steroidal Glycosides of Pei-Wujiapi(1).Chem.Pharm.Bull, 1968,16(2):326 ) in the disclosed technology, the extraction of Cyperus chinensis is with 95% ethanol as a solvent, and the extraction efficiency of barley toxin is relatively low
Afterwards, there was no report on the extracting process of Cortex Persicae, and there was no report on the preparation of an effective extract of Cortex Persicae for strengthening the heart

Method used

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  • Effective extract of Chinese silkuine bark with cardotonic function and its preparing process and uasge
  • Effective extract of Chinese silkuine bark with cardotonic function and its preparing process and uasge
  • Effective extract of Chinese silkuine bark with cardotonic function and its preparing process and uasge

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Experimental program
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Effect test

Embodiment 1

[0033] (1) Extraction of Chinese herbal medicine: 500g of Xiangjiapi, add 3000mL of 80% ethanol solution by volume, reflux extraction 3 times, each time for 2 hours, combine the extracts, concentrate under reduced pressure to about 400mL, add 600mL of water to dilute After filtration, the clarified Persica citrifolia aqueous solution was obtained;

[0034] (2) Adsorption and separation of macroporous resin: use the pretreated 800mL D 101 After the macroporous resin (produced by Tianjin Pesticide Factory) was adsorbed, it was washed with 800mL of water, pre-washed with 800mL of 30% ethanol, and then eluted with 1600mL of 95% ethanol. 17.5 grams of the effective extract with the effect of strengthening the skin and strengthening the heart, the ointment yield is 3.5%, and the mass percentage of the barley toxin is 3.18%. (If the aqueous solution of the extracted Perigoba bark is not treated with the macroporous resin, the yield of the extract is 21.3%, and the mass percentage of...

Embodiment 2

[0037] Effects of Effective Extracts from Cortex Persicae on Cardiac Function in Isolated Hearts

[0038] 24 healthy rats were selected and randomly divided into 3 groups: the blank control group, the effective extract group A of Xiangjiapi, and the group B of the pre-washed part of Xiangjiapi, with 8 rats in each group. The rats were decapitated and quickly removed. The heart was placed in 4°C K-H solution, the residual blood was gently drained, the heart was connected to the Langendorff system perfusion device and fixed with silk thread, and the perfusion was started. The perfusate was maintained at 37°C and 95% oxygen was introduced. Connect the ECG electrodes. After the ECG is stable, adjust the perfusion pressure at about 46±3mmHg and the perfusion flow at 6.00±0.06ml / min for constant pressure and constant flow perfusion. After stabilization, record the left ventricular systolic pressure (LVSP) before administration. ), left ventricular end-diastolic pressure (LVEDP), max...

Embodiment 3

[0043] (1) Extraction of the medicinal materials of Cyperus cyperi: add 4000mL of 40% ethanol solution by volume to 500g of Cortex cypress, carry out percolation extraction, concentrate the extract under reduced pressure to about 500mL, add 500mL of water to dilute and filter to obtain clarified Persica bark aqueous solution;

[0044] (2) Adsorption and separation of macroporous resin: Adsorb the aqueous solution of Cyperus barbata with pretreated 800mL AB-8 macroporous resin (produced by Nankai University Chemical Factory), elute with 8000mL 50% ethanol, and decompress the eluent The solvent was evaporated to dryness, and 31.0 g of the effective extract of Xiangjia Pixinteng was obtained, the yield of the paste was 6.2%, and the mass percentage of the barleytoxin was 1.65%.

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Abstract

The invention discloses the effective extract of Chinese silkuine bark with cardotonic function and its preparing process and use thereof, where the preparation process includes, (1) abstraction of Chinese silkuine bark by using 40%-80% alcohol or 40%-100% methyl alcohol as extracting agent, purifying through macroscopic adsorption resin column, eluting with 2-10 times of resin bed volume ethanol, collecting the eluent, concentrating, and drying.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to an effective extract of a traditional Chinese medicine for treating acute and chronic congestive heart failure, a preparation method of the effective extract and the use in preparing medicine for treating acute and chronic congestive heart failure. Background technique [0002] Xiangjiapi is the dried root bark of the Astragalus plant, which is believed to have the effect of dispelling rheumatism and strengthening bones and muscles. Because Xiangjiapi has the effects of strengthening the heart and diuresis, in recent years, Xiangjiapi has often been used in the clinical treatment of CHF with other traditional Chinese medicines for nourishing qi, warming yang, dispelling blood stasis, and diuresis. Xinyin, Qijia Granules, Beiwujiapi Mixture, Xinshuiling, etc. From the perspective of its preparation process, they are all compound recipes with all ingredients used as me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P9/04
Inventor 张伯礼刘虹高秀梅潘桂湘郭俊华朱晓薇
Owner TIANJIN TASLY PHARMA CO LTD
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