Preparation method for high purity lumbrukinase and pharmaceutical preparation made therefrom

A lumbrokinase, high-purity technology, applied in the field of preparation of high-purity lumbrokinase
CN1603405AInactive Publication Date: 2005-04-06BEIJING SAISHENG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING SAISHENG PHARMA
Publication Date
2005-04-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a high-purity earthworm activating enzyme preparation method and take it as raw material preparation. The invention through uses the monoclonal antibody technology realization earthworm activating enzyme, this method characteristic is attains the enzyme the shift strongly, the activeness is high, achieves above each milligram protein 200,000 units; After the highly effective liquid chromatography test is the sole component; Swims in the Sds- polyacrylamide gelatin electricity presents a belt, the molecular weight is 32000+ / -2000 Dalton; The amino acid sequence analysis, the N- terminal 10 amino acids sequences are: He-Val-Gly-Gly-He-Glu-Ala-Arg-Pro-Tyr, take states the high-purity earthworm activating enzyme to be allowed to make as the raw material medicine may supply to take orally, intermuscular injection, as well as the intravenous injection and the venous transfusion many kinds of ways for the medicine preparation, uses in the thrombus disease treatment.
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Description

technical field

[0001] The invention relates to a preparation method of lumbrokinase, more specifically, to a preparation method of high-purity lumbrokinase and pharmaceutical preparations prepared therefrom in various dosage forms for oral administration, intramuscular injection and intravenous administration. Background technique

[0002] The high morbidity, high mortality and high disability of thrombotic diseases seriously threaten the survival of human beings, and thrombolytic drugs are the first choice for the treatment of this disease. At present, there are common side effects that easily cause bleeding in the thrombolytic drugs used clinically; some are expensive and unbearable for ordinary people; some have poor stability and require high storage conditions, which brings a lot of inconvenience to drug users; The kind of drug administration mode is single, only has oral, or only has intravenous or intramuscular injection, and the scope of use medicine is very limited...

Claims

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