Eye formulation administering system containing lecithin and sodium hyaluronic acid and its preparing method

A technology of sodium hyaluronate and drug delivery system, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and medical preparations with non-active ingredients. Difficult to blink etc.

Inactive Publication Date: 2005-07-06
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the shortcomings of artificial tears are: 1. It does not contain natural lipids, and there is a lack of artificial tears for the treatment of excessive tear evaporation type xerophthalmia
It can be seen that most of the current artificial tears cannot effectively treat dry eyes caused by the lack of lipid layer.
② Cannot simulate the three-layer structure of normal tear film
③Poor biocompatibility
Although synthetic polymers can increase the viscosity of eye drops and prolong the residence time of the liquid in the eye to improve the curative effect, the synthetic polymers used are basically Newtonian fluids. When the viscosity increases to a certain extent, it will cause Eyelids do not blink easily and are irritating to the eyes

Method used

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  • Eye formulation administering system containing lecithin and sodium hyaluronic acid and its preparing method
  • Eye formulation administering system containing lecithin and sodium hyaluronic acid and its preparing method
  • Eye formulation administering system containing lecithin and sodium hyaluronic acid and its preparing method

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Embodiment 1

[0043] The ophthalmic drug delivery system of the present invention comprises 0.1 gram of lecithin, 0.1 gram of sodium hyaluronate, 0.85 gram of sodium chloride, 0.05 gram of borax, 0.05 gram of vitamin E acetate, and the rest is purified water in 100 mL.

Embodiment 2

[0045] The ophthalmic drug delivery system of the present invention, in 100mL, contains 0.1 gram of lecithin, 0.1 gram of sodium hyaluronate, 0.75 gram of sodium chloride, 0.3 gram of propylene glycol, 800.3 gram of Tween, 0.05 gram of borax, 0.05 gram of vitamin E acetate, and the rest are purified water.

Embodiment 3

[0047] The ophthalmic drug delivery system of the present invention, in terms of 100 mL, contains 0.1 g of lecithin, 0.1 g of sodium hyaluronate, 0.75 g of sodium chloride, 0.3 g of propylene glycol, 800.3 g of Tween, 0.05 g of borax, 0.05 g of vitamin E acetate, and hydroxybenzene 0.03 g of ethyl ester, and the rest is purified water.

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Abstract

The invention relates to an eye formulation administering system containing lecithin and sodium hyaluronic acid and its preparing method, wherein the system can directly serve as artificial tears to be applied to the treatment of xerophthalmia and other ophthalmology diseases. The system may also include other active constituents.

Description

Technical field: [0001] The invention relates to an ophthalmic drug delivery system containing lecithin (English: lecithin or phosphatidylcholine, also called phosphatidylcholine) and sodium hyaluronate (English: sodium hyaluronate, also called sodium hyaluronate) and a preparation method thereof. It belongs to the field of pharmaceutical technology. Background technique: [0002] Clinically, the dryness of the eyeball surface caused by the lack and abnormal distribution of tear film components is called xerophthalmia. Abnormalities in the lipid, aqueous, and mucus layers of the tear film, as well as abnormalities in the ocular surface, can cause xerophthalmia. The pathogenesis of xerophthalmia is complex. Among them, the lack of lipid layer is one of the main causes of xerophthalmia. There are many other causes of dry eye, such as aging, autoimmune diseases such as Sjogren's syndrome (Sjögren's syndrome), vitamin A deficiency, blocked lacrimal ducts, chronic conjunctivit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61K45/00A61K47/36A61P27/04
Inventor 凌沛学王凤山荣晓花陈翊
Owner 凌沛学
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