Unlock instant, AI-driven research and patent intelligence for your innovation.

Novel mitiglinide crystalline form and its preparing process

A technology of crystal form and interplanar spacing, which is applied in the field of new crystal forms, compositions containing it and its preparation, to achieve the effects of good stability, controllable product quality, and good crystal form stability

Inactive Publication Date: 2011-05-04
FOSHAN YIBAOSHENG PHARMA CO LTD
View PDF10 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no public report on the crystal form of mitiglinide in the existing literature

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel mitiglinide crystalline form and its preparing process
  • Novel mitiglinide crystalline form and its preparing process
  • Novel mitiglinide crystalline form and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 5 grams of mitiglinide into a 250ml flask, add 50ml of ethanol at room temperature to dissolve it, add 2.5ml of water, shake well, place overnight for crystallization, filter, wash with 10% water-ethanol, and dry in vacuum at 40°C for 8 hours. A new crystal form of mitiglinide with a purity of 90% was obtained.

Embodiment 2

[0035] Add 5 grams of mitiglinide to a 250ml flask, add 25ml of methanol at room temperature to dissolve it, add 2.5ml of water, shake well, place overnight for crystallization, filter, wash with 20% water-methanol, and vacuum dry at 40°C for 8 hours. The new crystal form of mitiglinide with a purity of 88% was obtained.

Embodiment 3

[0037] Add 5 grams of mitiglinide to a 250ml flask, add 200ml of isopropanol at room temperature to dissolve it, add 5ml of water, shake well and place it overnight for crystallization, filter, wash with 5% water-isopropanol, and vacuum dry at 45°C After 8 hours, a new crystal form of mitiglinide with a purity of 85% was obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a novel crystalline form of mitiglinide drug for treating diabetes, composite comprising same and its preparation process. Mitiglinide is a medicine for treating Type-11 diabetes, and its chemical name is (-)-2(s)-benzyl-4-oxy-4-(cis-perhydro iso indole -2-yl) calcium butyrate dihydrate. The novel crystalline form has high stability.

Description

Technical field: [0001] The invention relates to a crystal form of a medicine for treating diabetes, especially a new crystal form of mitiglinide, a composition containing it and a preparation method thereof. Background technique: [0002] The chemical name of mitiglinide is (—)—2(S)—benzyl—4—oxo—4—(cis-perhydroisoindol—2—yl) butyric acid calcium salt dihydrate. Miglinide is a new type of drug for the treatment of type II diabetes. Compared with traditional sulfonylurea drugs, it has a rapid onset of action and a short duration of action after administration. It can inhibit postprandial hyperglycemia characteristic of type II diabetes and has high safety. , good tolerance; compared with repaglinide and nateglinide, which belong to the same class of meglitaide, it has stronger efficacy. Relevant information disclosure has: U.S. Patent US6133454, US5202335; European Patent EP 0967204; Chem.Pharm.Bull.1997,45(9):1518~1520 and 1998,46(2):337~340; (10): 1034-1042. There is no ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/44A61K31/4035A61K9/00A61P3/10
Inventor 姚勇敢
Owner FOSHAN YIBAOSHENG PHARMA CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com