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Chlorretadin oral disintegrating tablet and its preparation method

A technology of loratadine and orally disintegrating tablets, which is applied in the field of pharmaceutical preparations, can solve problems such as inconvenience, achieve rapid onset of action, simple preparation process, and improve drug compliance

Inactive Publication Date: 2005-08-24
浙江现代中药与天然药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, when patients take medicine with water, especially the elderly and women and children, it is often very inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Store all raw materials in a dry and airtight container; control the humidity in the operating room below 70% relative humidity; weigh each component respectively; mix 0.28 grams of essence, 5 grams of loratadine, 72.32 grams of mannitol, and 28.5 grams of bicarbonate Sodium, 38.5 grams of citric acid, 3.08 grams of aspartame, 22.7 grams of cross-linked PVP, and the mixture are combined together, then add 2.72 grams of absolute alcohol, and mix well; pass the compound through a 60-mesh sieve, so that all can pass through Sieve; mix the sieved compound in a V-type blender for 30-60 minutes; add 1.9 grams of magnesium stearate, continue to stir and mix for 5-10 minutes; compress the tablet with a pressure of 2500-4000 pounds; pack the tablet Into a well-tight and moisture-proof glass bottle with a screw cap.

[0023] The total mass of auxiliary materials is 170 grams, and it is made into 1000 tablets, each auxiliary material is 170 grams, and the main drug is 5 grams, tha...

Embodiment 2

[0025] Store all raw materials in a dry and airtight container; control the humidity of the operating room below 70% relative humidity; weigh each component separately; mix 1 gram of essence, 10 grams of loratadine, 70 grams of mannitol, and 30 grams of bicarbonate Sodium, 30 grams of citric acid, 4 grams of aspartame, 30 grams of cross-linked PVP, and the mixture are combined together, then add 3 grams of absolute alcohol, and mix well; pass the compound through a 60-mesh sieve, so that all can pass through Sieve; mix the sieved compound in a V-type blender for 30-60 minutes; add 2 grams of magnesium stearate, continue to stir and mix for 5-10 minutes; compress the tablet with a pressure of 2500-4000 pounds; pack the tablet Into a well-tight and moisture-proof glass bottle with a screw cap.

[0026] The total mass of auxiliary materials is 170 grams, and 1000 tablets are made, each tablet is 170 grams of auxiliary materials and 10 grams of main drug, that is, the weight of or...

Embodiment 3

[0028] Store all raw materials in a dry and airtight container; control the humidity in the operating room below 70% relative humidity; weigh each component respectively; mix 0.5 grams of essence, 20 grams of loratadine, 80 grams of mannitol, and 25 grams of bicarbonate Sodium, 25 grams of citric acid, 3 grams of aspartame, 32 grams of cross-linked PVP, and the mixture are combined together, then add 4.5 grams of absolute alcohol, and mix well; pass the compound through a 60-mesh sieve, so that all can pass through Sieve; mix the sieved compound in a V-type blender for 30-60 minutes; add 2 grams of magnesium stearate, continue to stir and mix for 5-10 minutes; compress the tablet with a pressure of 2500-4000 pounds; pack the tablet Into a well-tight and moisture-proof glass bottle with a screw cap.

[0029] The total mass of auxiliary materials is 170 grams, and it is made into 1000 tablets, each tablet is 170 grams of auxiliary materials and 20 grams of main drug, that is, th...

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PUM

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Abstract

An oral disintegrating tablet of loratadine for treating allergic rhinitis, urticaria and other allergic skin diseases is prepared from loratadine and medicinal auxiliary.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an antihistamine pharmaceutical preparation, especially an orally disintegrating tablet of loratadine and a preparation method thereof. Background technique [0002] The main pharmacological effects of antihistamines can be divided into two categories: antihistamine effects and direct effects on effectors. Clinically, it is mainly used for allergic diseases of skin and mucous membranes. Such as allergic rhinitis, acute and chronic urticaria, etc. [0003] People suffering from allergic rhinitis, acute and chronic urticaria and other allergic skin diseases must take it with boiled water. On the one hand, when patients take medicine with water, especially the elderly and women and children patients, it is often very inconvenient. On the other hand, the drug disintegrates rapidly in the oral cavity, which can greatly improve the drug effect (bioavailability) and play a role quickly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4545A61P11/02A61P37/08
Inventor 王新蕾姜迅知李欣
Owner 浙江现代中药与天然药物研究院有限公司
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