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Compositions for solubilizing lipids

A composition, lipid technology, applied in the directions of detergent compositions, lens cleaning compositions, organic cleaning compositions, etc., can solve problems such as eye irritation

Inactive Publication Date: 2005-09-14
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of nonionic surfactants alone for cleaning contact lenses appears to be quite limited in terms of cleaning effectiveness at low concentrations and is known to cause eye irritation at higher concentrations

Method used

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  • Compositions for solubilizing lipids
  • Compositions for solubilizing lipids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0036] Embodiment 1-Preparation of test solution:

[0037] A multipurpose lens care sample solution for testing was prepared according to the formulation shown in Table 1 below.

[0038] Table 1

[0039] Multipurpose Lens Care Test Solution

[0040] Composition %W / W Test Solution 1

[0041] Pluronic P127 2.00

[0042] Tetronic 1107 1.00

[0043] Monosodium phosphate 0.15

[0044] Disodium phosphate 0.31

[0045] Boric acid 0.85

[0046] PHMB(ppm) 1.1

[0047] Sodium chloride 0.26

[0048] Dequest TM 2016 (30%) 0.1

[0049] Polyquaternium 10 0.02

[0050] pH 7.0

[0051] Osmolality (mOsm / Kg) 300

[0052] Dequest TM 2016 = sodium diphosphate

[0053] PHMB = poly(hexamethylene biguanide)

Embodiment 2

[0054] Example 2 - Preparation of test solution:

[0055] A lens drop sample solution for testing was prepared according to the formulation shown in Table 2 below.

[0056] Table 2

[0057] Lens Drop Test Solution

[0058] Composition % W / W Test Solution 2

[0059] Pluronic P127 2.00

[0060] Tetronic 1107 1.00

[0061] Tromethamine 0.121

[0062] Sodium borate 0.134

[0063] EDTA-Na 0.05

[0064] Glycerin 1.0

[0065] Sodium chloride 0.38

[0066] Sorbic acid 0.165

[0067] Polymer JR TM 0.02

[0068] pH 7.0

[0069] Osmolality (mOsm / Kg) 305

[0070] EDTA = ethylenediaminetetraacetic acid

Embodiment 3

[0071] The cleaning effect of embodiment 3-test solution:

[0072] The lipid-cleaning effect of several test solutions was examined by the lipid-dissolving velocity method. Specifically, the lipid, available under the trade name Super Sterol Ester TM C purchased from Croda Incorporated, Parsippany, New Jersey 10-30 Cholesterol / Lanosterol Esters, and available under the trade name Sudan I TM Dyes commercially available from Aldrich Chemical Company, Milwaukee, Wisconsin were used to generate lipid solutions that were used to determine the lipid cleaning efficacy of several test solutions. A lipid solution was created by heating 9.9 grams of supersterol ester to melt. Once melted, add 0.1 g of Sudan I and mix well. The mixture was a homogeneous red wax at room temperature which liquefied on slight heating. Place 5 drops of the liquefied lipid solution into the glass test tube, making sure that all the droplets collect together. Once the lipid solution in the tube has coo...

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Abstract

Compositions and methods for cleaning contact lenses employing nonionic surfactants having HLBs greater than about 18 with the nonionic surfactant having a greater HLB present in an amount about twice that of the nonionic surfactant having a lower HLB, and provided in an amount effective to reduce the amount of lipids on the contact lenses, thus rendering the contact lenses easier to clean. Additionally, by soaking contact lenses in the composition prior to inserting the lens on the eye, the compositions provide a prophylactic effect in preventing lipid deposition while the contact lens is worn.

Description

technical field [0001] The present invention relates to relatively mild compositions for solubilizing lipids. Surprisingly, it has been found that using Tetronic 1107 in a lipid dissolving composition in a weight ratio of about 2:1 TM (BASF, Mount Olive, New Jersey) and Pluronic F127 TM (BASF) dissolve lipids more effectively than using them at other weight ratios. Contains Tetronic 1107 in a weight ratio of about 2:1 TM and Pluronic F127 TM The compositions of the present invention are used in medicine, such as cleaning body tissues and medical devices contaminated with lipids. This composition is particularly useful for cleaning silicone hydrogel high DK lenses. The formulations according to the invention are so mild that they can be used directly in situ in or on the human body. Background technique [0002] Generally, contact lenses are divided into nonabsorbent and absorbent contact lenses, and into hard and soft contact lenses. Lipid deposition or contamination ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02C7/04A61L12/14C11D1/00C11D1/40C11D1/66C11D1/72C11D1/825C11D1/835C11D3/00C11D3/04C11D3/06C11D3/20C11D3/37C11D3/48G02C13/00
CPCC11D1/825A61L12/14C11D1/008C11D3/0078C11D1/40C11D1/835C11D1/72C11D1/66
Inventor 胡珍泽约瑟夫·C.·萨拉莫内
Owner BAUSCH & LOMB INC
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