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Solanesol refining method

A refining method and technology of solanesol, applied in chemical instruments and methods, preparation of organic compounds, preparation of hydroxyl compounds, etc., can solve the problems of complicated operation process, low production efficiency, large solvent consumption, etc., and achieve simplified refining process, increase product yield, and reduce cost

Inactive Publication Date: 2005-10-05
杨群力 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have following shortcoming: 1, production scale is small, and production efficiency is not high
2. The solvent consumption in the production process is relatively large, and the operation process is complicated, resulting in high production costs
3. The loss of solanesol in the production process is large, and the yield is not ideal
4. A large amount of organic solvents are used to reduce the safety factor of the product

Method used

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  • Solanesol refining method

Examples

Experimental program
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Effect test

Embodiment 1

[0016] 1. Put the solanesol crude paste extracted from tobacco leaves into a saponification tank, add 10% KOH aqueous solution for saponification treatment for 30 minutes under the condition of heating to 80°C and stirring vigorously, release the water layer after the end, and keep the oil layer , to obtain crude paste saponification;

[0017] 2. Put 10 kg of saponified solanesol crude paste into the extraction tank 4, turn on the heat exchanger 3, adjust the heating temperature to 50°C, turn on the compressor 2, and set the temperature at 30 m / min 3 The flow rate is passed into the extraction tank 4 with carbon dioxide fluid in a super-immediate state, so that the pressure in the extraction tank 4 reaches 14Mpa, and the pressure reducing valve is opened to extract the substances with molecular weight and polarity lower than solanesol in the phase paste and then extract them with the super The intermediary carbon dioxide fluid flows into the separation tank 5, and the extract ...

Embodiment 2

[0021] 1, the process is the same as embodiment 1;

[0022] 2. Put 10 kg of saponified solanesol crude paste into the extraction tank 4, turn on the heat exchanger 3, adjust the heating temperature to 80°C, turn on the compressor 2, and set the temperature at 100m / min 3 The flow rate is fed into the extraction tank 4 with carbon dioxide fluid in a super-immediate state, so that the pressure in the extraction tank 4 reaches 16Mpa, and the pressure reducing valve is opened to extract the substances with molecular weight and polarity lower than solanesol in the thick paste and then extract them with the super The intermediary carbon dioxide fluid flows into the separation tank 5, and the extract is precipitated after decompression. The pressure of the separation tank 5 is maintained at 4MPa, so that the supercritical carbon dioxide becomes gaseous carbon dioxide and enters the condenser 6, where it is continuously liquefied and then flows back The liquid storage tank 1 is re-inje...

Embodiment 3

[0026] 1, saponification process is with embodiment 1;

[0027] 2. Put 10 kg of saponified crude solanesol paste into the extraction tank 4, turn on the heat exchanger 3, adjust the heating temperature to 40°C, turn on the compressor 2, and set the temperature at 10 m / min 3 The flow rate is passed into the extraction tank 4 with carbon dioxide fluid in a super-immediate state, so that the pressure in the extraction tank 4 reaches 75Mpa, and the pressure reducing valve is opened to extract the substances with molecular weight and polarity lower than solanesol in the thick paste and then extract them with the super The intermediary carbon dioxide fluid flows into the separation tank 5, and the extract is precipitated after decompression. The pressure of the separation tank 5 is maintained at 5Pma, so that the supercritical carbon dioxide becomes gaseous carbon dioxide and enters the condenser 6, where it is continuously liquefied and then flows back The liquid storage tank 1 is ...

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Abstract

This invention provides a solanesol refining method, including pre-treatment of solanesol crude cream with zymolysis and alkali saponification, and making eater key formed from solanesol and organic acid break off. Its characteristics also include: supercritical extraction purifying, decompressing separation purifying, modified extraction purifying. This invention greatly simplifies the refining procedure and improves the yield of products in order to lower the cost and overcomes many weak points of present techniques, and greatly decreases the exhaustion of industrial residues to aim the low cost, high efficiency, scalization and environmental protection. It is a method with high industrial value.

Description

technical field [0001] The invention relates to a method for preparing solanesol, in particular to a method for refining solanesol. technical background [0002] Solanesol is a synthetic coenzyme Q 10 and vitamin K 2 It is also an important intermediate for the manufacture of anti-allergic drugs, anti-ulcer drugs, hypolipidemic drugs, anti-cancer drugs, etc. Most of them exist in animal organs and plant leaves, especially in tobacco. At present, the production methods of high-purity solanesol mostly adopt various column chromatography methods, such as a method for purifying solanesol disclosed in Chinese patent literature with application number 00123921. These methods have following shortcoming: 1, production scale is small, and production efficiency is not high. If the calculation is based on the annual production of 10 tons of high-quality products, a huge column chromatography system is required. 2. The solvent consumption in the production process is relatively lar...

Claims

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Application Information

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IPC IPC(8): C07C29/84C07C33/02C12P7/02
CPCY02P20/54
Inventor 杨群力吴建华
Owner 杨群力
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