Domperidone drip pill and its preparation method

A technology of dipperidone dripping pills and domperidone, applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of hepatic and intestinal first-pass bioavailability, which is not conducive to improving the ability of patients to seek medical treatment and the health of staff Harm and other issues, to achieve the effects of labor protection and environmental protection, improve bioavailability, and low labor intensity

A technology of dipperidone dripping pills and domperidone, applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of hepatic and intestinal first-pass bioavailability, which is not conducive to improving the ability of patients to seek medical treatment and the health of staff Harm and other issues, to achieve the effects of labor protection and environmental protection, improve bioavailability, and low labor intensity

CN1686128AInactive Publication Date: 2005-10-26北京博智绿洲医药科技有限公司
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] Now with several groups of specific examples, the preparation method of domperidone dripping pills of the present invention will be further described.

[0027] [Group 1: Trials with a single substrate]

[0028] 1. Domperidone: domestic product name Domperidone

[0029] 1.1 English name: Domperidone

[0030] 1.2 Chemical name: 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]piperidin-4-yl]- 1,3-Dihydro-2H-benzimidazol-2-one

[0031] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac and other pharmaceutically acceptable carriers;

[0032] 3. Proportion: take g or kg as the unit, by weight, domperidone: substrate = 1:1~1:9;

[0033] 4. Prepare according to the process given in [Preparation Method] 4-7, and different specification...

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Abstract

A dripping pill of domperidone for treating indigestion, nausea, vomiting, etc is prepared from domperidone and medicinal carrier.

Description

technical field [0001] The invention relates to a pharmaceutical composition with gastrointestinal prokinetic effect for treating dyspepsia, abdominal distension, belching, nausea and vomiting, in particular to an oral preparation of the pharmaceutical composition prepared from domperidone. Background technique [0002] Domperidone is a gastric motility and antiemetic drug developed by Janson Company in Belgium. It is used to treat functional, organic and infectious nausea, vomiting and non-ulcer dyspepsia. "Guidelines for Product Development" is a product recommended by the relevant state departments to concentrate on R&D and localization. The drug was first launched in Belgium in 1978 and has been successively launched in Germany, Italy, Britain, Japan, France and other countries, and has been widely used in countries all over the world. my country introduced this product in 1986, and Xi'an Janssen Company exclusively imported raw materials to produce preparations and sel...

Claims

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Application Information

Patent Timeline
26 Oct 2005
Publication
CN1686128A
IPC
A61K31/454
Inventors
曲韵智; 徐俊福