Domperidone drip pill and its preparation method

A technology of dipperidone dripping pills and domperidone, applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of hepatic and intestinal first-pass bioavailability, which is not conducive to improving the ability of patients to seek medical treatment and the health of staff Harm and other issues, to achieve the effects of labor protection and environmental protection, improve bioavailability, and low labor intensity

Inactive Publication Date: 2005-10-26
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug. , also directly affects the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparatio

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0026] Several specific examples are now used to further illustrate the preparation method of the domperidone dripping pill of the present invention.

[0027] [The first group: single matrix test]

[0028] 1. Domperidone: domestic trade name domperidone

[0029] 1.1 English name: Domperidone

[0030] 1.2 Chemical name: 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]piperidin-4-yl]- 1,3-Dihydro-2H-benzimidazol-2-one

[0031] 2. Matrix: polyethylene glycol 1000 Polyethylene glycol 4000 Polyethylene glycol 6000 Polyethylene glycol 10000 Polyethylene glycol 20000 , Span 40, Polyoxy 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac and other pharmaceutically acceptable carriers;

[0032] 3. Mixing ratio: in g or kg, in parts by weight, domperidone: matrix=1:1~1:9;

[0033] 4. According to the process given in [Preparation Method] 4-7, domperidone dripping pills of different specifications can be obtained.

[0034] [...

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PUM

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Abstract

A dripping pill of domperidone for treating indigestion, nausea, vomiting, etc is prepared from domperidone and medicinal carrier.

Description

technical field [0001] The invention relates to a pharmaceutical composition with gastrointestinal prokinetic effect for treating dyspepsia, abdominal distension, belching, nausea and vomiting, in particular to an oral preparation of the pharmaceutical composition prepared from domperidone. Background technique [0002] Domperidone is a gastric motility and antiemetic drug developed by Janson Company in Belgium. It is used to treat functional, organic and infectious nausea, vomiting and non-ulcer dyspepsia. "Guidelines for Product Development" is a product recommended by the relevant state departments to concentrate on R&D and localization. The drug was first launched in Belgium in 1978 and has been successively launched in Germany, Italy, Britain, Japan, France and other countries, and has been widely used in countries all over the world. my country introduced this product in 1986, and Xi'an Janssen Company exclusively imported raw materials to produce preparations and sel...

Claims

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Application Information

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IPC IPC(8): A61K31/454
Inventor 曲韵智徐俊福
Owner 北京博智绿洲医药科技有限公司
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