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Coated conditioners for use in foods and pharmaceuticals

A conditioner and coating technology, which is applied in the forming of food, food ingredients as anti-caking agent, food ingredients as encapsulant, etc., can solve the problems of wet powder and poor flow performance

Inactive Publication Date: 2005-11-02
J M HUBER CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the common pain reliever acetaminophen (N-acetyl-p-aminophen) has a compact crystalline form and the powder often creates pressure and wet clumps in storage, resulting in poor flow performance
Commercial fumed silicas, such as Cab-O-Sil M5 from Cabot Corporation, Bellrica, Massachusetts, provide improved flow behavior, but they do not completely solve the problem

Method used

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  • Coated conditioners for use in foods and pharmaceuticals
  • Coated conditioners for use in foods and pharmaceuticals
  • Coated conditioners for use in foods and pharmaceuticals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] In Examples 1-8, a coating conditioner consisting of a mixture of stearic acid compound and inorganic particles was prepared according to the invention. The median particle size and oil absorption values ​​for the inorganic particles are given in Table A below (methods for determining particle size and oil absorption values ​​are discussed below).

[0027]In this process, first, a certain amount of inorganic particles such as silica, calcium carbonate or kaolin (as shown in Table I below) was added to a mixing bowl and the mixing bowl was connected to a Kitchen Aid Heavy Duty K5SS type mixer. To control the temperature of the mixing bowl contents, a heat jacket is added around it to heat the mixing bowl to increase the temperature of the mixing bowl contents. The temperature of the mixing bowl contents was measured by a thermocouple in contact with the mixing bowl contents, and the temperature was electronically regulated by a solid-state temperature controller connecte...

Embodiment 26-29

[0042] In Examples 26-29, a coating conditioner consisting of a mixture of mineral oil and precipitated silica was prepared according to the invention. First, 100 grams of precipitated silica (shown in Table III below) was added to a mixing bowl attached to a laboratory grade Hobart mixer. With the mixer turned on at low speed, 4.0% or 10.0% mineral oil was added and allowed to mix with the silica for 10 minutes at ambient temperature (as shown in Table III below).

[0043] Example number

Inorganic substances

mineral oil increase

26

Zeofree 80

4％

27

Zeofree 80

10％

28

Zeothix 265

4％

29

Zeothix 265

10％

[0044] The potential of a powder to form a wet cake can be assessed using the wet cake test. A baseline correlation between moisture and unconditioned drug or food powder caking was determined prior to actual testing of the conditioned powder in the moisture cake itself (ie, drug...

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PUM

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Abstract

An edible composition comprising a coated conditioner that contains a hydrophobization agent and inorganic particles is provided. When incorporated into an edible composition (such as a powdered pharmaceutical or food product), the coated conditioners inhibit caking and promote the free flow of powder. Suitable hydrophobization agents include food-grade fatty acids, foodgrade oils, food-grade waxes, and food-grade gums, while suitable inorganic particles are selected from the group consisting of silica, silicates, calcium carbonates, phosphates, and clays. The coated conditioner is particularly suitable for use in pharmaceutical preparations, such as acetaminophen.

Description

Background technique [0001] Over the past few years, materials such as silica, sodium aluminosilicate, kaolin, tricalcium phosphate, and calcium silicate have been used as "conditioners" in dry and powdered foods to prevent caking and promote particle size in powdered foods. of free movement. Also, fumed silica has been widely used as an excipient (regulator or glidant) in pharmaceuticals. These conditioners absorb moisture from the air or packaging to prevent food particles from sticking together or clumping together when wet and act as "roll-on balls" coating the surface of food particles, thereby preventing agglomeration of adjacent particles. These conditioners, also considered free-flowing and anti-caking formulations, are permitted by the U.S. Food and Drug Administration at levels not exceeding or equal to 2.0% by weight of the finished food product. In addition these regulators may also have other applications such as fertilizers, pesticides and polymers. [0002] T...

Claims

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Application Information

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IPC IPC(8): A23L1/00A23L19/00A23L27/10A23L27/14A23L29/00A61K9/42
CPCA23L1/0032A23V2002/00A23L1/223A23L1/2121A23L1/0038A23L1/031A23L19/01A23L27/14A23L29/03A23P10/35A23P10/43A23V2200/224A23V2250/1628A23V2250/1886A23V2200/208A23V2250/212
Inventor J·M·科尼刘斯M·E·塔奎尼J·M·尼德斯G·M·弗里曼
Owner J M HUBER CORP
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