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Osmotic pumping sustained preparation of ropinirole hydrochloride and its preparing method

A technology of controlled-release preparations and osmotic pumps, applied in the field of ropinirole hydrochloride osmotic pump-type controlled-release preparations and its preparation, can solve problems such as static tremor, difficulty walking, and inability to fit, and achieve stable blood drug concentration and eliminate Peak and valley phenomenon, the effect of reducing symptom fluctuation

Inactive Publication Date: 2005-12-28
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, patients with Parkinson's disease have inconvenient activities, and the clinical manifestations are static tremor, stiffness, slow movement, difficulty in walking, etc. At the same time, the clinical treatment of Parkinson's disease requires long-term medication, and the existing dosage forms are far from being suitable for clinical use. need

Method used

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  • Osmotic pumping sustained preparation of ropinirole hydrochloride and its preparing method
  • Osmotic pumping sustained preparation of ropinirole hydrochloride and its preparing method
  • Osmotic pumping sustained preparation of ropinirole hydrochloride and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Osmotic pump controlled release tablet using lactose and mannitol in combination as osmotic pressure enhancer

[0022] Tablet prescription:

composition

Prescription A (mg / tablet)

Prescription B (mg / tablet)

Ropinirole Hydrochloride

13.68

27.36

lactose

89

178

Mannitol

89

178

pvp

4

8

Cross-linked PVP

4

8

Magnesium stearate

1.6

3.2

Theoretical core weight

201

402

Coating prescription:

Cellulose acetate

10g

10g

Polyethylene glycol-1500

0.8108g

0.8108g

[0023] Preparation: sieve and mix the prescribed amount of medicine with lactose, mannitol, PVP, and glue-linked PVP, use 90% ethanol to make a soft material, granulate with a 20-mesh sieve, dry in an oven at 40°C for 12 hours, and sieve through a 20-mesh sieve Granules, dry granules plus ...

Embodiment 2

[0025] Example 2 Osmotic pump controlled release tablet using lactose and mannitol in combination as osmotic pressure enhancer

[0026] Tablet Prescription:

Prescription A (mg / tablet)

Prescription B (mg / tablet)

Ropinirole Hydrochloride

6.84

3.42

lactose

92

93

Mannitol

92

93

pvp

4

4

Glue-linked PVP

4

4

Magnesium stearate

1.6

1.6

Theoretical film weight

209.5

209.2

Coating prescription:

Cellulose acetate

10g

Polyethylene glycol-1500

0.8108g

[0027] Preparation: sieve and mix the prescribed amount of medicine with lactose, mannitol, PVP, and glue-linked PVP, use 90% ethanol to make a soft material, granulate with a 20-mesh sieve, dry in an oven at 40°C for 12 hours, and sieve through a 20-mesh sieve Granules, dry granules plus lubricant magnesium stearate compressed into tablet c...

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PUM

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Abstract

The invention discloses a ropinirole hydrochloride osmotic pump type controlled release preparation and a preparation method thereof. The osmotic pump controlled release preparation consists of three parts: tablet core, semipermeable membrane and drug release hole. The tablet core is composed of ropinirole, osmotic pressure enhancer and other excipients, the semipermeable membrane contains film-forming materials and plasticizers, and the hole-making methods include mechanical drilling and laser drilling. Through the joint application of osmotic pressure enhancers and the adjustment of semi-permeable membrane parameters, the drug release rate can be controlled. After oral administration, the ropinirole osmotic pump-type controlled-release tablet can release the drug continuously for 24 hours or longer, which is more conducive to the clinical treatment of Parkinson's patients and is convenient for patients to take the drug.

Description

technical field [0001] The invention relates to a ropinirole hydrochloride osmotic pump type controlled release preparation and a preparation method thereof. The osmotic pump controlled release preparation consists of three parts: tablet core, semipermeable membrane and drug release hole. The tablet core is composed of ropinirole, osmotic pressure enhancer and other excipients, the semipermeable membrane contains film-forming materials and plasticizers, and the hole-making methods include mechanical drilling and laser drilling. Through the joint application of osmotic pressure enhancers and the adjustment of semi-permeable membrane parameters, the drug release rate can be controlled. After oral administration, the ropinirole osmotic pump-type controlled-release tablet can release the drug continuously for 24 hours or longer, which is more conducive to the clinical treatment of Parkinson's patients and is convenient for patients to take the drug. Background technique [000...

Claims

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Application Information

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IPC IPC(8): A61K31/404
Inventor 刘玉玲吴浩翔
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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