Adhesive material and adhesive preparation

A technology of adhesive and adhesive layer, applied in surgical adhesives, medical science, surgery, etc., can solve the problem of changing peelability and achieve good absorption effect

Active Publication Date: 2006-02-15
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no existing method that pays attention to changing the peelability during the period from the beginning of adhesion to the time of peeling so as to maintain good drug absorption and suppress skin damage caused by adhesion and peeling. Stimulate

Method used

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  • Adhesive material and adhesive preparation
  • Adhesive material and adhesive preparation
  • Adhesive material and adhesive preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-12

[0104] Embodiment 1-12, comparative example 1-5

[0105] Each of the compositions of Tables 1 to 4 was dissolved in toluene to obtain a coating solution having a solute concentration of 35%. This solution was coated on a silicone release-treated polyethylene terephthalate (PET) liner so that the coating thickness after drying was 120 μm. This liner was dried in a hot air circulating oven at 70° C. for 2 minutes, at 80° C. for 2 minutes, and at 95° C. for 3 minutes to obtain an adhesive layer. 2 μm thick PET film and PET nonwoven fabric (12 g / m 2 ) are adhered to each other to form a carrier, and the non-woven fabric surface of the carrier is laminated on the adhesive layer. The laminate was aged at room temperature for 2 days to obtain adhesive sheets of Examples 1-12 of the present invention and Comparative Examples 1-5.

[0106] For the measurement of apparent viscosity, a sample containing only an adhesive layer without laminating the above-mentioned carrier was recovere...

experiment Embodiment 1

[0141] Experimental Example 1 (Measurement of Apparent Viscosity and Measurement of Adhesive Force)

[0142] The apparent viscosity and adhesive force of the adhesive materials of Examples 1-12 and Comparative Examples 1-5 were measured as follows. The results are shown in Table 5.

[0143]

[0144] The above sample was measured according to JIS K7210 using a flow tester CFT-500C (manufactured by Shimadzu Corporation) under the following conditions, and the values ​​were calculated by the following formula. The sample density used is 1.0g / cm 2 .

[0145] [Measurement conditions]

[0146] Sample temperature: 30°C

[0147] Cylinder pressure: 30.0kgf / cm 2

[0148] Die used: L: 10.00mm, D: 1.00mm

[0149] Preheating time: 300s

[0150] Apparent shear stress: 7.36×10 5 dyn / cm 2

[0151] Measurement start position S 1 : 3mm

[0152] Measurement end position S 2 : 7mm

[0153] [Calculation formula]

[0154] Q = A · ...

experiment Embodiment 2

[0174] Experimental Example 2

[0175] Adhesive materials of Examples 1-12 and Comparative Examples 1-5 were prepared with a length of 10 cm and adhered to the inside of the antebrachial site of volunteers (n=3). After 2 hours, 1 day, 2 days and 3 days of adhesion, peelability was measured under the same conditions as the adhesion force measurement in Experimental Example 1 above. The peeling direction is the 90° direction. In addition, the presence or absence of pain at the time of peeling was also confirmed. The results for detachment are average, the results for the presence of pain follow the majority opinion. The results are shown in Table 6.

[0176] In Table 6, in the column of peeling pain, ○ means "no pain", △ means "a little pain", × means "quite painful", "Note 1" means "peeling is not possible due to cohesive failure", " Note 2" means "not measurable because the sample was detached from the adhesion site", and "Note 3" means "the sample was broken (repositione...

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Abstract

The present invention provides an adhesive material to be adhered to the skin etc., which maintains, for a certain time period after adhesion thereof to the skin surface, suitable adhesiveness that does not allow easy peeling or cause irritation to the skin, and which permits, when it is to be peeled off from the skin surface after the lapse of a desired certain time period, easy peeling without causing pain or physical irritation, and an adhesive preparation containing the adhesive material and a percutaneously absorbable drug in the adhesive layer. Specifically, the present invention provides an adhesive material containing a support and an adhesive layer laminated on one surface of the support, wherein the adhesive layer has an apparent viscosity at 30 DEG C. of 0.2x10<4>to 10x10<4>Pa.s and comprises two kinds of synthetic rubbers having different flowability.

Description

technical field [0001] The present invention relates to an adhesive material for adhering to a skin surface, the adhesive material comprising an adhesive layer laminated on one surface of a carrier, the adhesive material having a suitable Adhesive properties that can be easily peeled off when removed, and an adhesive formulation comprising a transdermally absorbable drug in an adhesive layer of an adhesive material. Background technique [0002] In recent years, various adhesive-type transdermally absorbable formulations for sustained administration of drugs from the skin surface have been developed and become commercially available. The technical direction pursued from now on is toward suppressing skin irritation that occurs when formulations are adhered and peeled off while maintaining excellent drug absorbability. [0003] However, too much emphasis is placed on inhibiting physical irritation upon peeling, which leads to an unnecessary reduction in adhesion, undesirably ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/04
Inventor 明见仁二宫和久黑田英利松冈贤介佐伯有史西村真人
Owner NITTO DENKO CORP
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