32results about How to "Does not cause irritation" patented technology

A topsheet for absorbent articles having absorbing performance for smoothly transferring liquid body waste, e.g., menstrual blood or urine, to an underlying absorbent member and surface characteristics such that the surface thereof in contact with wearer's skin is soft enough not to cause skin irritation. The topsheet 1 comprises a first layer 11 disposed on the side of a wearer and a second layer 12 disposed on the side of an absorbent member, the first layer and the second layer being partly joined together, and having protrusions and depressions on the side of a wearer, wherein the first and second layers each comprise a fiber aggregate, the first layer has fusion-bonded fiber intersections, the first layer has an apparent thickness (t1) of 0.1 to 5 mm, the second layer has an apparent thickness (t2) of 0.2 to 3 mm, the apparent thickness ratio of the first layer to the second layer (t1 / t2) is 0.5 to 8, the first layer has a fiber density (d1) of 0.001 to 0.05 g / cm<3>, the second layer has a fiber density (d2) of 0.03 to 0.2 g / cm<3>, and the fiber density (d2) of the second layer is higher than that (d1) of the first layer.

The invention relates to a sunscreen skin care product, which contains a sunscreen additive, wherein the sunscreen additive is peanut shell general flavones and / or flos sophorae general flavones or a mixture of the peanut shell general flavones, the flos sophorae general flavones and nanometer TiO2; when the peanut shell general flavones are added independently, the weight percentage of the peanut shell general flavones is 0.5 to 5 percent; when the flos sophorae general flavones are added independently, the weight percentage of the flos sophorae general flavones is 0.6 to 6 percent; and when the peanut shell general flavones and the flos sophorae general flavones are added to be compounded or the peanut shell general flavones and the flos sophorae general flavones are added to be compounded with the nanometer TiO2, the total addition amount of the peanut shell general flavones and the flos sophorae general flavones is 0.5 to 6 percent. According to the sunscreen skin care product, peanut shells or flos sophorae which is low in cost and readily available is used as raw materials, and flavonoid compounds which are contained in the peanut shells or the flos sophorae are extracted, and are blended scientifically and reasonably to form the sunscreen skin care product. The flavonoid compounds in the peanut shells or the flos sophorae have good functions of absorbing ultraviolet rays and repairing sunburned skin, and the prepared skin care product does not have adverse reaction such as irritation, allergy and the like or side effect on human bodies, has a good sunscreen effect, and is stable in quality and easy to produce and store.

The present invention relates to a matrix type patch for the transdermal delivery of a bronchodilator which is consisted of a backing layer, a pressure-sensitive adhesive layer comprising a drug, and a release liner, wherein the said pressure-sensitive adhesive layer comprises as the drug component at least one of brochodilators selected from a group consisting of formoterol, salmeterol, tulobuterol, clenbuterol and the like; cationic polymers enhancing skin-permeability of the said drug components; solubilizing agents of the drug components; and pressure sensitive adhesives. The matrix type patch according to the present invention provides high skin permeability of the drug by using cationic polymeric absorption enhancers, sustained duration of the drug action for a prolonged time and excellent adhesion to the skin without causing irritation.

Disclosed is a preparation which, in an orally fast-disintegrating tablet having as an active ingredient 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole carboxylic acid, causes basically no irritation in the mouth or throat, retains good dissolvability and oral disintegration even when stored under high temperature or high humidity conditions. The disclosed orally fast-disintegrating tablet is formed to contain particles comprising nuclear particles which contain 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole carboxylic acid, which are covered by a layer containing a methacrylic acid copolymer, and which are further coated with an outer layer containing water-soluble sugars, such that after two weeks of storage under conditions with the cap open at 40C / 75% RH, a dissolution test performed according to the Japanese Pharmacopoeia Paddle Method at 50 revolutions per minute (test solution: pH6.0McIlvaine buffer) evaluates the dissolution rate of the 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazole carboxylic acid at 70% or greater after 10 minutes.

An object of the present invention is to provide an agent for suppressing the formation of skin cells induced by exposure to light such as ultraviolet light. The object is achieved by using a purine nucleic acid for suppressing the formation of abnormal skin cells caused by exposure to light.

The invention discloses a preparation method of a biologically absorbable polyphosphate and amino acid copolymer material. The preparation method comprises the following steps: 1) dehydrating alpha-amino acid and caprolactam under the protection of inert gas at 150 DEG C to 200 DEG C; 2) reacting at 190 DEG C to 260 DEG C and finishing polymerization reaction to form a polymer with a multi-component amino acid amide structure; 3) adding phosphate and reacting at 200 DEG C to 260 DEG C for 0.5h to 2h and finishing ring-opening copolymerization reaction; cooling to room temperature under the protection of the inert gas to obtain a product. A polyphosphate and amino acid copolymer prepared by the method has good hydrophilcity and degrading performance, and good mechanical properties; the pH (Potential of Hydrogen) of a degraded product is 6.5 to 7.5 and stimulation reaction is not caused; the polyphosphate and amino acid copolymer has good effect when being used for in-vivo repairing and has good clinical application prospect.

The invention discloses a seaweed extract that can effectively relieve skin sunburn, and a preparation method and application thereof. The preparation method includes the following steps: weighing a certain amount of seaweed, adding 20 to 50 times the volume of water, leaching with boiling water for 0.5 h to 4 h, after cooling, the extract is centrifuged at 3000 g to 10000 g for 10 min to 15 min, and the centrifugation supernatant is successively passed through Suction filtration, ultrafiltration, collection of ultrafiltration retentate, concentration, freeze-drying, that is, it is obtained. The preparation method of the invention can remove components that do not significantly improve the activity of cells irradiated by ultraviolet rays, so that the active components in the seaweed extract that can effectively relieve skin sunburn are highly enriched, thereby improving the physiological efficacy of the seaweed extract and greatly reducing its dosage. The seaweed extract has high safety, can significantly reduce cell apoptosis and necrosis caused by ultraviolet radiation, reduce dermal inflammatory exudation and elastic fiber degradation, and effectively relieve skin UV sunburn.