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Matrix type patch containing bronchodilators

A bronchodilator and matrix technology, which can be used in medical preparations containing active ingredients, medical preparations without active ingredients, drug combinations, etc., and can solve the problems of low skin permeability and low adhesion.

Inactive Publication Date: 2005-08-10
AHN GOOK PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Therefore, it is an object of the present invention to provide a matrix-type patch capable of overcoming the delayed release of drugs, low skin permeability, and low adhesion of the adhesive layer to the skin.

Method used

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  • Matrix type patch containing bronchodilators
  • Matrix type patch containing bronchodilators
  • Matrix type patch containing bronchodilators

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The matrix-type patch of the present invention is produced as follows.

[0041] 400 mg of formoterol fumarate as a drug was added to 4 ml of methanol and completely dissolved to obtain a homogeneous solution. 1.4 g vinylpyrrolidone-dimethylaminoethyl methacrylate copolymer {poly(vinylpyrrolidone-co-dimethylaminoethyl methacrylate): "Copolymer 958" , manufactured by ISP TECHNOLOGIES, INC., USA} as cationic polymerization absorption accelerator; 2g laurylpyrrolidone and 0.4g triethanolamine as solubilizer; 0.6g vinylpyrrolidone-ethylene vinyl acetate copolymer {Poly(vinylpyrrolidone-co-vinyl vinyl acetate), PVP / VA I-735, I-535, I-335, made by ISPTECHNOLOGIES, INC., U.S.} as a polymer additive to increase viscosity Adhesion and bonding of the mixture layer; and 15.1 g of acrylic adhesive polymer solution "Duro-TAK 87-4098" (manufactured by National Starch Co., U.S.) as a base material with 50 mg of butylated hydroxytoluene (BHT) Together with 50 mg of butylated hydroxyan...

Embodiment 2～9

[0044] The composition (%) of each component used in Examples 2-9 is listed in Table 1, and the procedure is the same as described in Example 1.

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Abstract

The present invention relates to a matrix type patch for the transdermal delivery of a bronchodilator which is consisted of a backing layer, a pressure-sensitive adhesive layer comprising a drug, and a release liner, wherein the said pressure-sensitive adhesive layer comprises as the drug component at least one of brochodilators selected from a group consisting of formoterol, salmeterol, tulobuterol, clenbuterol and the like; cationic polymers enhancing skin-permeability of the said drug components; solubilizing agents of the drug components; and pressure sensitive adhesives. The matrix type patch according to the present invention provides high skin permeability of the drug by using cationic polymeric absorption enhancers, sustained duration of the drug action for a prolonged time and excellent adhesion to the skin without causing irritation.

Description

technical field [0001] The present invention relates to a matrix-type patch for treating respiratory diseases such as asthma, which patch provides high skin permeability by using a cationic polymer absorption enhancer. The patch also ensures sustained drug release and has excellent adhesion to the skin. Background technique [0002] Asthma is a chronic respiratory disease accompanied by various symptoms such as shortness of breath, cough, wheezing, sputum, and chest tightness. [0003] The prevalence of asthma is increasing recently, especially among children, and there is a general trend toward increased mortality and hospitalization for asthma. High mortality is often caused by adverse complications of drug therapy. [0004] The approach to asthma treatment is to use long-acting controller medications to maintain control of persistent asthma, and rapid-relief medications to manage symptoms and exacerbations. [0005] Drugs used in the treatment of asthma generally inclu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/137A61K47/34A61P11/00A61P11/08
CPCA61K9/7023A61P11/00A61P11/06A61P11/08A61K9/70
Inventor 崔永权柳贤硕申一均金希淑
Owner AHN GOOK PHARMA CO LTD
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