Matrix type patch containing bronchodilators

Abstract

The present invention relates to a matrix type patch for the transdermal delivery of a bronchodilator which is consisted of a backing layer, a pressure-sensitive adhesive layer comprising a drug, and a release liner, wherein the said pressure-sensitive adhesive layer comprises as the drug component at least one of brochodilators selected from a group consisting of formoterol, salmeterol, tulobuterol, clenbuterol and the like; cationic polymers enhancing skin-permeability of the said drug components; solubilizing agents of the drug components; and pressure sensitive adhesives. The matrix type patch according to the present invention provides high skin permeability of the drug by using cationic polymeric absorption enhancers, sustained duration of the drug action for a prolonged time and excellent adhesion to the skin without causing irritation.

Description

technical field

[0001] The present invention relates to a matrix-type patch for treating respiratory diseases such as asthma, which patch provides high skin permeability by using a cationic polymer absorption enhancer. The patch also ensures sustained drug release and has excellent adhesion to the skin. Background technique

[0002] Asthma is a chronic respiratory disease accompanied by various symptoms such as shortness of breath, cough, wheezing, sputum, and chest tightness.

[0003] The prevalence of asthma is increasing recently, especially among children, and there is a general trend toward increased mortality and hospitalization for asthma. High mortality is often caused by adverse complications of drug therapy.

[0004] The approach to asthma treatment is to use long-acting controller medications to maintain control of persistent asthma, and rapid-relief medications to manage symptoms and exacerbations.

[0005] Drugs used in the treatment of asthma generally inclu...

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