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Lycopene liposome and its prepn process

A technology of lycopene lipid and lycopene, which is applied in the directions of liposome delivery, antitoxin, anhydride/acid/halide active ingredients, etc., can solve the problems of easy oxidative degradation, limited application, unfavorable absorption and utilization, etc.

Inactive Publication Date: 2006-03-01
HEBEI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because it is a fat-soluble carotenoid, it is insoluble in water and is easily oxidatively degraded under the action of light and thermal oxygen, which greatly limits its application in the fields of food, health products, cosmetics, etc. Application, especially as an oral health product, is not conducive to the absorption and utilization of the human body

Method used

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  • Lycopene liposome and its prepn process
  • Lycopene liposome and its prepn process
  • Lycopene liposome and its prepn process

Examples

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Embodiment 1

[0020] Example 1, preparation of lycopene liposomes: Weigh an appropriate amount of cholesterol and lecithin (the mass ratio of the two is 0.1-0.25: 1) and add a certain amount of organic solvent (ether or trichloromethane or dichloromethane, wherein Lycopene has the greatest solubility in dichloromethane), preferably dichloromethane. After completely dissolving, dissolve 0.01-0.05g lycopene into it to obtain a lipid solution; put half of the lipid solution in a 250ml ground-mouth pear-shaped flask, and then place the pear-shaped flask in a constant temperature water bath at 25-35°C , use a rotary evaporator to volatilize the organic solvent under the conditions of rotating speed 80-140r / min and decompression (the pressure is maintained at 0.02-0.06Mpa), so that film-forming materials such as lecithin form a uniform lipid film on the flask, and then add to the flask Charge N 2 5-10min, the solvent is completely removed; add an appropriate amount of PBS (PH=7.3-7.4) solution c...

Embodiment 2

[0021] Example 2, preparation of lycopene liposomes: Weigh an appropriate amount of cholesterol and lecithin (the mass ratio of the two is 0.1-0.25:1) and add dichloromethane. After being completely dissolved, 0.03g of lycopene was dissolved in it to obtain a lipid solution; half of the lipid solution was placed in a 250ml ground-mouthed pear-shaped flask, and glass beads with a diameter of 3-4mm were added at the same time, and then the pear-shaped Place the flask in a constant temperature water bath at 25-35°C, use a rotary evaporator to volatilize the organic solvent under the conditions of a rotating speed of 80-140r / min and a reduced pressure (the pressure is maintained at 0.02-0.06Mpa), so that lecithin and other film-forming materials are in the flask. A uniform lipid film is formed on the wall and glass beads, and then the flask is filled with N 25-10min, the solvent is completely removed; add an appropriate amount of PBS (PH=7.3-7.4) solution containing 0.05% Tween 80...

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Abstract

The present invention is lycopene liposome as one new preparation form of lycopene, and the lycopene liposome is prepared through dissolving lycopene organic solution containing lecithin and cholesterol of solvent ethyl ether, dichloromethane or trichloromethane and further film rotating ultrasonic process. The material includes lycopene, cholesterol and lecithin in the weight ratio of 1-5 to 10-25 to 100. The lycopene liposome consists of double liposome molecule layer with inside large water phase monolocular veside of effective grain size 0.7 micron and maximum enclosing rate 52.6 %. The lycopene liposome has target property, no toxicity and no immunogenicity, and may be clinically used to reduce medicine dosage, raise absorption efficiency, lower toxicity, increase the solubility and stability of lycopene and raise bioavailability.

Description

technical field [0001] The invention relates to a dosage form of medicine, namely lycopene liposome and a preparation method thereof. Background technique [0002] Lycopene is a strong antioxidant, which has the physiological functions of quenching singlet oxygen and scavenging free radicals. It can prevent the occurrence of many diseases and has a good application and development prospect. However, because it is a fat-soluble carotenoid, it is insoluble in water and is easily oxidized and degraded under the action of light and thermal oxygen, which greatly limits its application in the fields of food, health products, cosmetics, etc. Application, especially as an oral health care product, is not conducive to the absorption and utilization of the human body. Liposome is a closed vesicle composed of a lipid bilayer with an aqueous phase inside, ranging in size from tens of nanometers to tens of microns. Various substances can be wrapped in the aque...

Claims

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Application Information

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IPC IPC(8): A61K31/557A61K9/127A61P39/06
Inventor 常彦忠田艳燕段相林
Owner HEBEI NORMAL UNIV
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