Unlock instant, AI-driven research and patent intelligence for your innovation.

Foamable pharmaceutical compositions and methods for treating a disorder

A kind of mixture, pharmaceutical technology, applied in the diseases of skin and mucous membranes, delivery of foamable pharmaceutical composition, preparation of foamable pharmaceutical composition, can solve the problems such as harmful foam stability

Inactive Publication Date: 2006-06-28
斯蒂菲尔实验室公司
View PDF16 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the presence of a rigid, condensed surface film is detrimental to foam stability due to minimal variation in regions where the foam exhibits elasticity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Foamable pharmaceutical compositions and methods for treating a disorder
  • Foamable pharmaceutical compositions and methods for treating a disorder
  • Foamable pharmaceutical compositions and methods for treating a disorder

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0352] Other acids known to be useful in the preparation of foamable compositions are also within the scope of the present invention.

[0353] Acids for inclusion in the compositions of the present invention are selected to maintain the pH of the composition suitably in the range of about 2 to about 10. Depending on the particular active therapeutic agent contained in the composition, the optimum pH of the composition, the acid used to maintain the optimum pH and the amount of acid will vary. As will be appreciated, the selection of the optimum pH for each particular active agent, and the optimum type and amount of acid to achieve that optimum pH, is within the ordinary knowledge of those of ordinary skill in the art.

[0354] other ingredients

[0355] In addition to the active therapeutic agent and the foamable delivery system, the pharmaceutical formulations of the present invention may contain other non-essential optional ingredients suitable for topical foams known to th...

Embodiment 1

[0473] The following examples illustrate the preparation of the foamable pharmaceutical composition that is the subject of the present invention:

[0474] weight percentage (%)

[0475] Clobetasol Propionate 0.05

[0476] Poloxamer 188 1.60

[0477] Citric acid buffer 0.15

[0478] Ethanol 60.0

[0479] Polysorbate 60 0.10

[0480] Propylene glycol 2.00

[0481] Purified water 31.6

[0482] Propellant (propane-isobutane) 4.50

[0483] 100.0%

[0484] Preparation of the composition:

[0485] 1. The raw materials other than the propellant are mixed by conventional means to form an aerosol concentrate.

[0486] 2. The concentrate is then filled into aerosol containers such as aluminum tubes.

[0487] 3. The propellant is then added via conventional procedures such as fill through valve or under cup fill.

Embodiment 2

[0489] The following examples illustrate the preparation of the foamable pharmaceutical composition that is the subject of the present invention:

[0490] weight percentage (%)

[0491] Betamethasone valerate 0.10

[0492] Laureth-4 3.00

[0493] Phosphate buffer 0.20

[0494] Ethanol 65.0

[0495] Sodium diethylhexyl succinate 1.00

[0496] Glycerin 3.00

[0497] Purified water 23.4

[0498] Propellant (propane-isobutane) 4.30

[0499] 100.0%

[0500] Preparation of the composition:

[0501] 1. The raw materials other than the propellant are mixed by conventional means to form an aerosol concentrate.

[0502] 2. The concentrate is then filled into aerosol containers such as aluminum tubes.

[0503] 3. The propellant is then added via conventional procedures such as fill through valve or under cup fill.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Novel compositions of matter comprising a foamable delivery system are provided. Novel methods for treating a disease, disorder, or condition using the novel compositions are further provided. Novel methods for making and delivering a foamable pharmaceutical composition are also provided. While the novel compositions and foamable drug delivery system may be utilized for administration of a wide variety of drugs to epithelial tissues, to treat a wide variety of diseases, disorders, or conditions, the inventive compositions and foamable drug delivery systems are particularly useful for the dermatological administration of corticosteroids and antifungal agents.

Description

technical field [0001] The subject of the present invention relates to new foamable drug delivery systems. The subject of the invention is also pharmaceutical compositions and methods of treating diseases, disorders or conditions using the drug delivery systems of the invention. The present invention also relates to methods for preparing foamable pharmaceutical compositions and methods for delivering foamable pharmaceutical compositions. Although these foamable drug delivery systems can be utilized to deliver various drugs to epithelial tissues for the treatment of various diseases, disorders or conditions, the appearance, metabolic or functional state, permeability and For pharmaceutical actives and / or health, the foamable drug delivery system of the present invention is particularly useful in the treatment of diseases affecting the skin and mucous membranes of mammals. Background technique [0002] Foamable dosage forms are generally suitable for topical administration t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/57A61K9/12A61K31/415A61K47/02A61K47/10A61K47/12A61M11/00
CPCA61K9/122A61K47/02A61K47/10A61K47/12A61P17/00A61K9/12A61K31/19A61K31/415A61K31/57
Inventor 卡尔·F·波普爱德华·R·尤哈斯
Owner 斯蒂菲尔实验室公司