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Method for preparing N ¿C acetyl ¿C D - glucosamine ú¿NAG)

A technology of glucosamine and acetyl, which is applied in the field of preparing N-acetyl-D-glucosamine by using a catalyst, can solve the problems of long production cycle, high production cost, incomplete reaction and the like, and achieves low production cost, short production cycle, biological good compatibility

Inactive Publication Date: 2006-07-05
济南海得贝海洋生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional production method does not respond completely, pollutes the environment, has high production costs, and has a long production cycle.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] In a 1000L non-plastic reaction tank, add 300KG dried snow crab shells, then add 5% hydrochloric acid solution, and react at room temperature for 10 hours until the crab shells are softened, and the acidic solution after the reaction is discharged for disposal. Soften the crab shell and wash it with water for 3 times until the pH is 6, filter it, put the filtered product into a stainless steel reactor, add 3% NaOH solution, heat it up to 100°C, react for 3 hours, discharge the waste lye to be treated, and wash the filtered product with water for 4 hours , to PH to 7, and sun-dried to obtain 65KG of special-purpose chitin, with a yield of 21.7%.

[0011] Put 60kg of special chitin into a 500L enamel reaction kettle, add 300kg of 30% hydrochloric acid, raise the temperature to 90°C, and react for 5 hours. Then decolorize, filter, concentrate, crystallize, separate, and dry to obtain product 2, namely GAH solution, with a GAH yield of 65%.

[0012] In a 500L reactor, meth...

Embodiment 2

[0014] In a 2000L non-plastic reaction tank, add 600KG dried snow crab shells, then add 5% hydrochloric acid solution, and react at room temperature for 10 hours until the crab shells are softened, and the acidic solution after the reaction is discharged for disposal. Soften the crab shell and wash it with water for 3 times until the pH is 6, filter it, put the filtered product into a stainless steel reactor, add 3% NaOH solution, heat it up to 100°C, react for 3 hours, discharge the waste lye to be treated, and wash the filtered product with water for 4 hours , to PH to 8, dried in the sun, and 130KG of special chitin was obtained.

[0015] Add 120kg of special chitin into a 1000L enamel reaction kettle, add 900kg of 20% hydrochloric acid, raise the temperature to 60°C, and react for 3 hours. Then decolorize, filter, concentrate, crystallize, separate, dry, GAH solution.

[0016] In a 1000L reactor, methanol was added as a solvent, organic bases such as pyridine and propylam...

Embodiment 3

[0018] In a 1000L non-plastic reaction tank, add 300KG dried snow crab shells, then add 5% hydrochloric acid solution, and react at room temperature for 10 hours until the crab shells are softened, and the acidic solution after the reaction is discharged for disposal. Soften the crab shell and wash it with water for 3 times until the pH is 6, filter it, put the filtered product into a stainless steel reaction kettle, add 3% NaOH solution, heat it up to 100°C, react for 1 hour, discharge the waste lye for treatment, and wash the filtered product with water for 4 times , to PH to 9, and dried in the sun to obtain 65KG of special chitin with a yield of 21.7%.

[0019] Put 60kg of special chitin into a 500L enamel reaction kettle, add 250kg of 35% hydrochloric acid, raise the temperature to 100°C, and react for 6 hours. Then decolorize, filter, concentrate, crystallize, separate and dry to obtain a GAH solution with a GAH yield of 65%.

[0020] In a 500L reactor, methanol was add...

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Abstract

This invention relates to a preparation method for N-acetyl-D-aminoglucose (NAG), which includes: a) raw materials chitin and hydrochloric acid (20~35%) are mixed with a mass ratio of 1:3~1:6 and react with each other at a temperature of 60~100 deg.C for 3~6 hours. The mixture is then decolorized, filtered, condensed, crystallized, separated and dried to obtain GAH solution; b) composite catalysts are added; c) AC2O is added with a GAH / AC2O mole ratio of 1:2~1:6 and the pH value is adjusted to 6~10. The solution is stirred and the reaction is kept at a temperature of 0~50 deg.C for 1~4 hours; d) the mixture is filtered with 2~5ª–m microfiltration membrane, crystallized and filtered again. The filtrate is heated, condensed with reverse osmotic membrane and crystallized. The consequent crystals are washed with methanol, ethanol and acetone, purified and dried so as to obtain product NAG.

Description

technical field [0001] The invention relates to a method for preparing N-acetyl-D-glucosamine (NAG), in particular to a method for preparing N-acetyl-D-glucosamine (NAG) by using a catalyst. Background technique [0002] N-acetyl-D-glucosamine (NAG for short) is the basic unit of many important polysaccharides in biological cells, especially the exoskeleton of crustaceans has the highest content, and has many important physiological functions in living organisms. It can enhance the function of the human immune system and treat rheumatism and rheumatoid arthritis clinically. It can inhibit the excessive growth of cancer cells or fibroblasts, inhibit and treat cancer and malignant tumors; it can effectively treat various inflammations. In addition to medicine, it has remarkable effects in treating cancer, preventing cancer, lowering cholesterol, losing weight, increasing calcium, etc. It is also an important precursor for the synthesis of bifidus factor and hyaluronic acid. ...

Claims

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Application Information

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IPC IPC(8): C07H5/06C07H15/12
Inventor 赵连军李兴福陈雯雯
Owner 济南海得贝海洋生物工程有限公司
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