Acidian polypeptide and preparation method thereof

A technology of sea squirt polypeptide and sea squirt, which is applied in the field of sea squirt polypeptide and its preparation, and can solve problems such as applications that have not been reported yet
CN1803831AInactive Publication Date: 2006-07-19SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2006-07-19
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The low-cost preparation method for polypeptide sea squirts with sequence as formula (I), 666.3 molecular weight and anti-HBV function comprises: dipping with ethanol at normal temperature to prepare extract after ethanol recovery; extracting the extract with organic solvent to condense, separate and purify by in turn the chromatography with macroporous resin, silica gel with gradient elution with CHCl3, MeOH and H2O by ratio as 7:3:0.5, and Sephadex LH20; collecting and condensing the eluent with Rf as 0.2-0.3 for ultraviolet detection label in TLC.
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Description

field of invention

[0001] The invention belongs to the field of biochemistry and biomedicine, and specifically relates to ascidian polypeptide and a preparation method thereof. Background technique

[0002] Ascidia is a Uronordata subphylum Uronordata, and a few of the anticancer components extracted from Ascidia have entered the clinical or preclinical stage. Studies have found that sea squirts contain dozens of compounds such as alkaloids, peptides, indoles, heavy metal chelating agents, polysulfides, macrolides, and terpenes, which have strong antitumor, antiviral, and antibacterial properties. , Inducing sarcoplasmic reticulum to release calcium, inhibiting calmodulin activity and other physiological activities, especially anti-tumor research reports (Li Zhijun, Xue Changhu, Wang Changhai. Anti-tumor bioactive substances in sea squirts. Ocean Bulletin, 2004, 23(5):82-86; Ji Yubin, Chi Wenjie. Research on anti-tumor active substances in sea squirts. Journal of Harbin Uni...

Claims

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