New medicinal use of paeonidin

A technology of paeoniflorin and medicine, which is applied in the field of new medical use of paeoniflorin, and can solve problems such as unreported

Inactive Publication Date: 2006-08-02
SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Paeoniflorin is extracted from Radix Paeoniae Rubra, Radix Paeoniae Alba, and Cortex Moutan, and forms an amorphous powder with hygroscopicity. Many effects such as ischemia and inhibition of platelet aggregation, but there is no report about the effect of paeoniflorin on preventing and treating postoperative recovery of intestinal function and preventing intestinal adhesion; Application of glucoside in preparation of medicine for preventing or treating postoperative intestinal function recovery and preventing intestinal adhesion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0015] Preparation Example 1: Preparation of Paeoniflorin

[0016] Take 10kg of Radix Paeoniae Rubra and 70% ethanol to reflux and extract 3 times, 1.5h each time, 30L each time, combine the extracts, filter, recover to dryness under reduced pressure, heat and dissolve the residue with an appropriate amount of water, filter with suction, and add the filtrate to a pre-filled On a good macroporous adsorption resin column (the ratio of dry paste and resin is 15:20), after slowly adding it dropwise, first wash it with water until the reaction of reducing sugar is negative (Molish reaction detection), and use 20% concentration instead. The ethanol was eluted, the eluent was combined, and the eluent was recovered to dryness under reduced pressure to obtain 530 g of total paeony glycosides, which was added to a pre-packed silica gel column, and eluted with chloroform-methanol (1:10), the eluent was combined, and the eluent was reduced. Compress and recover to dryness, wherein the con...

preparation example 2

[0017] Preparation Example 2: Preparation of Paeoniflorin

[0018] Take 20kg of paeonol medicinal material (origin: Tongling), crush it into coarse powder, put it into an extraction tank; add 200L of water to boil for 2 times, each time for 2h, after filtering, concentrate under reduced pressure to about 30L; apply macroporous adsorption resin The column was fully eluted with water until the effluent was clear and there was no reducing sugar reaction, and then eluted with 40% ethanol; the eluate was collected, concentrated under reduced pressure, extracted twice with chloroform, recovered chloroform, and added 95% ethanol to the aqueous solution to make Alcohol concentration is 80%. Let it stand for 0.5h, filter off the precipitate, and recover the filtrate to dryness under reduced pressure to obtain 1 kg of paeonol glycosides raw material. The content of total glycosides in the total glycosides of paeony in the effective parts is 66%, and the content of paeoniflorin as the m...

preparation example

[0019] Preparation Example Preparation of Paeoniflorin Freeze-dried Powder for Injection

[0020] Under clean conditions, take the paeoniflorin obtained in the preparation example, dissolve it in water for injection, add low-molecular dextran, stir to dissolve, and perform ultrafiltration to obtain a pyrogen-free clear liquid. Each one is freeze-dried according to the freeze-dried powder injection process to prepare into the freeze-dried powder injection contained in each tube.

[0021] Preparation Example Preparation of Paeoniflorin Injection

[0022] Under clean conditions, take the paeoniflorin obtained in the preparation example, dissolve it in water for injection, stir to dissolve, and perform ultrafiltration to obtain a pyrogen-free clarified liquid. According to the injection preparation process, one injection containing paeoniflorin is made.

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PUM

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Abstract

The present invention provides the application of paeonidin in preparing medicine for promoting post-operational intestinal function and preventing post-operational intestinal adhesion.

Description

technical field [0001] The invention relates to the application of paeoniflorin in the preparation of drugs for promoting intestinal function recovery after operation and preventing intestinal adhesion. Background technique [0002] Abdominal surgery is the most common operation in surgery. Generally, the intestinal function of patients after surgery is relatively weak. The recovery of intestinal function after surgery is of great significance to the recovery of patients, including the recovery of diseases, and the reduction of intestinal adhesions and other complications. [0003] Restoration of intestinal function after surgery is mainly to restore a certain intensity of intestinal peristalsis, but because you cannot eat after surgery, premature gastric peristalsis may cause upper abdominal discomfort due to the absence of food in the stomach. It has been reported in the literature that the rate of intestinal adhesions in various degrees after abdominal surgery is as high ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/00A61P43/00
Inventor 蒋王林高玉白田京伟傅风华
Owner SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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