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Use of indole-2,3-dione for preparing medicine for cardio-cerehral vascular disease

A kind of cardiovascular and cerebrovascular disease, diketone technology, applied in indole-2

Inactive Publication Date: 2006-08-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there is no report on the use of marine active substance MW147 for the preparation of cardiovascular and cerebrovascular disease drugs

Method used

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  • Use of indole-2,3-dione for preparing medicine for cardio-cerehral vascular disease
  • Use of indole-2,3-dione for preparing medicine for cardio-cerehral vascular disease
  • Use of indole-2,3-dione for preparing medicine for cardio-cerehral vascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of tablet

[0016] Indole-2,3-dione 100mg

[0017] Lactose 100mg

[0018] Starch 295mg

[0019] Magnesium Stearate 5mg

[0020] Total 500mg

[0021] Weigh out the above-mentioned ingredients respectively, mix the indole-2,3-dione crystals and crush the powder, lactose, and starch through an 80-mesh sieve, granulate by wet method, dry, mix with magnesium stearate after integration, and press Tablets made into tablets with a weight of 500 mg each.

Embodiment 2

[0022] Embodiment 2: the preparation of capsule

[0023] Indole-2,3-dione 100mg

[0024] Starch 395mg

[0025] Magnesium Stearate 5mg

[0026] Total 500mg

[0027] Each of the above-mentioned ingredients was weighed out, mixed evenly with indole-2,3-dione crystalline powder passed through a 80-mesh sieve, carefully filled into capsules, and made into capsules each with a net weight of 500 mg.

[0028] After clinical trials, the results are as follows:

[0029] 1. MW147 20, 60, 120 mg·kg-1 doses of prophylactic drugs can reduce the degree of AS lesions in the aorta and coronary arteries of high-fat baited AS quails; the same dose of MW147 therapeutic drugs can promote the regression of AS.

[0030] 2. MW147 20, 60, 120 mg·kg-1 preventive medication and therapeutic medication can reduce serum TC, TG, LDL-C, apoB levels, and increase HDL-C, apoA levels (P<0.05, P<0.01) , has the effect of regulating lipid metabolism disorder.

[0031] 3. MW147 20, 60, 120mg kg-1 can increas...

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Abstract

The present invention discloses an application of indole-2.3-diketone (MW147) in preparation of medicine for preventing and / or curing angiocardiopathy and cerebrovascular disease. Said MW147 has the action of preventing formation of AS and promoting repercussion of AS, so that it can be made into the medicine for resisting As.

Description

technical field [0001] The present invention relates to a new application of indole-2, 3-dione (MW147, indole-2, 3-dine), in particular to the application of indole-2, 3-dione in the preparation of cardiovascular and cerebrovascular disease drugs . Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the leading causes of human death, and are common and frequently-occurring diseases that seriously threaten human health and life. Among them, atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases, so the research on anti-AS drugs has been paid more and more attention. In recent years, with the rapid development and interpenetration of cells, sub-cells, pathophysiology, molecular biology, immunochemistry, modern genetics and other disciplines, new progress has been made in the study of the etiology of atherosclerosis. Theories such as damage and lipid peroxidation modification provide new possible tar...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61P9/10A61P3/06
Inventor 岳旺刘占涛杨志宏仲伟珍王蕾徐敏
Owner QINGDAO UNIV
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