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Use of chrysanthemum total flavone for preparing drugs for treating arythmia

A technology for arrhythmia and total flavonoids is applied in the application field of chrysanthemum total flavonoids in the preparation of drugs for treating arrhythmia, which can solve the problem of not many varieties, and achieve the effects of clear effect, good antiarrhythmic effect, and increased indications.

Active Publication Date: 2006-08-09
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many varieties of antiarrhythmic Chinese patent medicines at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Chrysanthemum total flavonoids against aconitine-induced arrhythmia in rats

[0013] SD rats, half male and half female, weighing 240g-280g, were randomly divided into four groups and anesthetized by intraperitoneal injection (ip) of 1.2g / kg urethane. The supine position was fixed, the femoral vein was exposed, and the retained needle was placed. Adopt standard limb leads, connect to PcLab machine, record electrocardiogram, respectively ip total flavonoids of chrysanthemum, solvent 1.4ml / kg, salvia miltiorrhiza injection 6.0g / kg. After 20 minutes, 30 μg / kg of aconitine was injected. Observation indicators: premature ventricular contraction (VE), ventricular tachycardia (VT), ventricular fibrillation (VF) appearance time, duration (number of occurrences) and end time, and arrhythmia score (Score). See Table 1 and Table 2 for the results.

[0014] Table 1 Chrysanthemum total flavonoids on aconitine-induced arrhythmia in rats

[0015] ...

Embodiment 2

[0021] Example 2 Chrysanthemum total flavonoids against chloroform-induced arrhythmia in mice

[0022] NIH mice, half male and half female, body weight 20g-25g, were randomly divided into three groups, respectively intraperitoneally injected (ip) 120mg / kg chrysanthemum total flavonoids, 30mg / kg quinidine, 4.2ml / kg solvent, after 10min, each Rats were put into 500ml glass covers respectively, and cotton balls soaked with 2ml chloroform were placed in advance in the covers. When the mice stopped breathing for 5 seconds, they were taken out and connected to lead electrocardiograms to observe the incidence rate of ventricular fibrillation (VF) and rhythm of the mice. Rate. The results are shown in Table 3.

[0023] group

number of animals

Number of VF occurrences

Number of turns

solvent

quinidine

Chrysanthemum total flavonoids

10

10

10

8

7

3 *

0

5 **

2 *

[0024] Note: Compared with normal ...

Embodiment 3

[0026] Example 3 Effect of total flavonoids from chrysanthemum on arrhythmia caused by coronary artery ligation

[0027] Beagle dogs, male and female, aged 1-2 years, weighing 8-10kg, were randomly divided into 6 groups, and the total flavonoids of chrysanthemum were packed into "0" capsules for dogs to take.

[0028] (1) Blank control group: feeding with blank capsules for 7 days, and giving 10 ml of normal saline via duodenum before operation.

[0029] (2) Model control group: feeding with blank capsules for 7 days, and giving 10 ml of normal saline through the duodenum before operation.

[0030] (3) Low-dose total chrysanthemum flavonoids group: 17 mg / kg / day x 7 days of chrysanthemum total flavonoids were given, and 17 mg / kg chrysanthemum total flavonoids were given via duodenum before operation.

[0031] (4) Medium-dose chrysanthemum total flavonoids group: 34 mg / kg / day of chrysanthemum total flavonoids was administered for 7 days, and 34 mg / kg of chrysanthemum total flav...

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PUM

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Abstract

The present invention provides an application of chrysanthemum total flavone in preparation of medicine for cuing arrhythmia. The chrysanthemum total flavone provided by said invention is effective component of chrysanthemum flower, the total flavone content is geater than 50%, and the dosage form prepared by using chrysanthemum flavone and medicinal exipient can be liquid preparation and solid preparation. Its therapeutic effect is obvious and reliable.

Description

technical field [0001] The invention belongs to the use of traditional Chinese medicine, and relates to the application of total flavonoids of chrysanthemum in the preparation of medicines for treating cardiovascular diseases, in particular to the application of total flavonoids of chrysanthemums in the preparation of medicines for treating arrhythmia. Background technique [0002] Cardiac arrhythmia is a common disease. Various types of heart disease, high blood pressure, senile emphysema, etc. can induce arrhythmia, and malignant arrhythmia can be life-threatening in an instant. Therefore, the prevention and treatment of arrhythmia is of great significance. However, clinical studies have shown that various types of antiarrhythmic chemicals are proarrhythmic [1，2] , so antiarrhythmic Chinese medicine will be more and more favored by doctors and patients. However, there are not many varieties of antiarrhythmic Chinese patent medicines. Chrysanthemum is a common medicinal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/16A61K9/20A61K9/48A61K9/08A61K9/10A61P9/06
Inventor 蒋惠娣夏强曾苏曹春梅
Owner ZHEJIANG UNIV
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