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Pharmaceutical composition for treating depression, its preparation method and application

A composition and technology for depression, applied in drug combination, pharmaceutical formula, drug delivery, etc., can solve the problems that depression has not been widely used, and no traditional Chinese medicine for depression has been approved for marketing, so as to achieve clear mechanism of action and good curative effect Effect

Inactive Publication Date: 2006-10-04
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the data, so far, traditional Chinese medicine has not been widely used in the treatment of depression, and the country has not yet approved the listing of specific Chinese medicine for the treatment of depression.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Bupleurum 150g White peony root 200g Angelica 200g Acacia peel 200g

[0038] Polygala 150g, Poria 150g, Shichangpu 150g

[0039] The volatile oil of 150g Shichangpu was extracted by steam distillation, and the volatile oil was collected in another container; Shichangpu medicinal residues were mixed with the above-mentioned amount of Bupleurum, Baishao, Angelica, Albizia Julibrissin, Polygala, Poria, and 60% ethanol was added for reflux extraction (2 times). The amount of ethanol added was 12 times and 8 times respectively), and each time was extracted for 1.5 hours; the extracts were combined, filtered, and the ethanol was recovered under reduced pressure and concentrated to a relative density of 1.32-1.38 (50 ° C) to prepare a thick extract; 1 part of thick extract, 1 part of dextrin, 1 part of sucrose powder, mixed evenly, granulated, vacuum-dried, granulated, and added with volatile oil of calamus to prepare granules.

Embodiment 2

[0041] Bupleurum 180g Baishao 200g Angelica 180g Acacia peel 180g

[0042] Polygala 150g, Poria 150g, Shichangpu 160g

[0043] The volatile oil of 160g Shichangpu was extracted by steam distillation, and the volatile oil was collected in another container; Shichangpu medicinal residues and the above-mentioned amount of Bupleurum, Baishao, Angelica, Acacia bark, Polygala, Poria were extracted with water for 2 times (the amount of water added for 2 times was respectively 10 times, 7 times), each extraction for 1.5 hours; the extracts were combined, filtered, concentrated under reduced pressure to a relative density of 1.10-1.15 (65°C), cooled to room temperature, and slowly added 95% ethanol while stirring until the alcohol content reaches 60%, let stand for 24 hours; filter the alcohol precipitation liquid, recover ethanol under reduced pressure and concentrate to a relative density of 1.32-1.38 (50°C) to prepare a thick extract; take 1 part of thick extract, 1 part of dextrin,...

Embodiment 3

[0045] Bupleurum 180g Baishao 180g Angelica 180g Acacia peel 150g

[0046] Polygala 180g, Poria 150g, Shichangpu 180g

[0047] The volatile oil of 180g Shichangpu was extracted by steam distillation, and the volatile oil was collected in another container; the Shichangpu medicinal residues and the above-mentioned amount of Bupleurum, Baishao, Angelica, Acacia bark, Polygala, Poria were extracted by adding water twice (the amount of water added for 2 times was respectively 10 times, 7 times), each extraction for 1.5 hours; the extracts were combined, filtered, concentrated under reduced pressure to a relative density of 1.10-1.15 (65°C), cooled to room temperature, and slowly added 95% ethanol while stirring until the alcohol content reaches 60%, let stand for 24 hours; the alcohol precipitation liquid is filtered, ethanol is recovered under reduced pressure and concentrated to a relative density of 1.35-1.40 (50° C.), vacuum-dried, pulverized, and prepared into dry extract pow...

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PUM

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Abstract

The invention relates to a Chinese medicinal compound for treating recession, the preparing process and use, wherein the medicinal composition comprises (by weight portions): bupleurum root 2-4 parts, white peony root 3-5 parts, Chinese angelica root 3-5 parts, mimosa-tree bark 3-5 parts, polygala root 2-4 parts, poria cocos wolf 2-4 parts, acorus gramineus soland 2-4 parts.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound pharmaceutical composition for treating depression, a preparation method and application thereof. Background technique [0002] With the progress of the society and the development of the economy, the material living standard of human beings has been greatly improved, but it is also accompanied by hidden mental pressure, resulting in depression, self-blame, boredom, loss, irritability, depression, tension and emotions. and mental disorders. These are increasingly disturbing the lives of modern people. The World Health Report 2001 published by the World Health Organization emphasized that depression has now become the fourth largest disease in the world, and by 2020 it may become the second largest disease after heart disease. Every year, October 10th has been designated as "World Mental Health Day". It can be seen that depression has become one of the serious disease factors affecting ...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P25/24
Inventor 彭继道李林苏金平赵玲魏海峰王文李雅莉
Owner XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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