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Minoxidil solution and preparing method of minoxidil liniment tablet

A technology of minoxidil and minoxidil alcohol, which is applied in the field of minoxidil topical preparations, can solve the problems of difficulty in mastering the dosage, unsafe hidden dangers, high skin irritation and the like

Active Publication Date: 2006-11-08
深圳市天明医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These preparations are more irritating to the skin, difficult to control the dosage, and have problems such as potential safety hazards in the use of these preparations.

Method used

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  • Minoxidil solution and preparing method of minoxidil liniment tablet

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preparation example Construction

[0028] According to the preparation method of the smear of minoxidil solution of the present invention, be that it adopts the minoxidil solution that above-mentioned method makes to fill in the smear bag, each smear contains minoxidil solution 0.5~ 3.0 ml, the pads are composed of absorbent paper, cotton, synthetic fiber or their composite material carrier with a surface area of ​​10-50 square centimeters, and are packed in an airtight bag made of aluminum plastic, plastic, paper or their composite materials.

[0029] In order to prepare quality more stable, the minoxidil solution that skin irritation is less, its component has been studied, made the minoxidil solution of the present invention, especially has made the smear, it is a kind of dosage A new dosage form that is accurate, safe, effective and convenient to use.

Embodiment 1

[0030] Embodiment 1: the composition ratio of preparing every 1000 milliliters of 2% minoxidil solution is:

[0031] Minoxidil 20g,

[0032] 1,2-propanediol 200ml,

[0033] 95% ethanol 600ml,

[0034] Sodium thiosulfate 2 g,

[0035] Tetrabutylamine hydrochloride 0.2 g,

[0036] Add water to 1000ml.

[0037] The preparation method of every 1000 milliliters of 2% minoxidil solution: get 200 milliliters of 1,2-propanediol, 600 milliliters of 95% ethanol, heat to 40 ℃, add 20 grams of minoxidil, stir to dissolve, and make rice For the minoxidil alcohol solution, add 2 grams of sodium thiosulfate and 0.2 grams of tetrabutylamine hydrochloride to 20 milliliters of water, stir to dissolve, add this solution to the above-mentioned minoxidil alcohol solution, stir well, add water to 1000 ml to prepare 1000 ml of 2% minoxidil solution.

Embodiment 2

[0038] Embodiment 2: the preparation method of the smear of 2% minoxidil solution: the solution composition ratio that it contains, preparation method are the same as embodiment 1, the 2% minoxidil solution prepared by embodiment 1 is filled in the smear In the sheet bag, each sheet contains 1 milliliter of minoxidil solution, and the sheet is made of absorbent paper with a surface area of ​​25 (5cm×5cm) square centimeters, and is packed in an aluminum-plastic composite bag.

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Abstract

The present invention relates to alopecia areata treating externally applied medicine preparation, and is especially preparation process of minoxidil solution and minoxidil liniment sheet. The minoxidil solution is prepared with minoxidil, 1, 2-propylene glycol, ethanol, sodium thiosulfate, tetrabutyl ammonium hydrochloride and water in certain proportion. The preparation process includes dissolving minoxidil in 1, 2-propylene glycol and ethanol solution through heating to 40 deg.c; dissolving sodium thiosulfate and tetrabutyl ammonium hydrochloride in water; and mixing to obtain the minoxidil solution. The minoxidil solution is added to base sheet of water absorbing carrier in surface area of 10-50 sq cm to form the minoxidil liniment sheet, which is sealed in bag for maintenance.

Description

Technical field: [0001] The invention belongs to the field of minoxidil external preparations for treating alopecia areata and alopecia, in particular to a preparation method of a minoxidil solution and a patch thereof. Background technique: [0002] Minoxidil (MINOXIDIL, composed of 6-(1-piperidinyl)-2,4-pyrimidinediamine, 3-oxide) was synthesized by the Upjohn laboratory in the United States in 1963 and is used for the treatment of hypertension. molecular drug. In 1979, the U.S. Food and Drug Administration (FDA) approved the oral dosage form of the drug. In the early clinical research on the antihypertensive effect of minoxidil, it was found that patients who took it for more than 1 month had hirsutism. People such as Weiss reported first in 1981: with 1% minoxidil solution topical treatment the patient of severe alopecia areata, the people that has 2 / 3 grew new hair. As early as 1986, 28 medical centers in the United States treated 2326 patients with male pattern bald...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61K9/08A61K9/70A61P17/14
Inventor 王颖实
Owner 深圳市天明医药科技开发有限公司
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