Animal skin penetrant

A technology of animal skin and penetrant, applied in the direction of medical preparations with non-active ingredients, organic active ingredients, medical preparations containing active ingredients, etc., can solve problems that have not been generally recognized and valued by the pharmaceutical industry

Inactive Publication Date: 2006-11-08
新疆维吾尔自治区畜牧科学院兽医研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the recognition of the microcirculation theory of mammalian organisms, the continuous in-depth research on the mechanism of pharmaceutical preparations, and the extensive development and application of skin penetration aids and skin absorbers, there are some achievements in the use of skin drug delivery and treatment of diseases. Incipient, but not generally recognized and valued by the pharmaceutical industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 (preparation of praziquantel skin penetration agent): total volume percentage

[0019] Mix 40% dimethyl sulfoxide and 10% methyl salicylate to make liquid I;

[0020] Dissolve 12.5% ​​of the original powder (weight percentage) of praziquantel (purity above 90%) in 50% absolute ethanol at a temperature of 50-90°C to prepare II liquid, accounting for 50% of the total volume;

[0021] Then the prepared liquid I and liquid II are mixed to obtain the praziquantel skin penetrating agent.

[0022] When in use, it is prepared according to the weight of the animal and the sensitivity of the drug to the animal, and the prepared drug is dropped into the midline of the back of the animal.

Embodiment 2

[0023] Embodiment 2 (abamectin or the skin penetration agent of ivermectin): total volume percentage

[0024] Mix 50% dimethyl sulfoxide and 20% methyl salicylate to make liquid I;

[0025] Dissolving 5% of Abamectin or ivermectin (more than 80% purity) powder (weight percentage) in propylene glycol is prepared into II liquid, accounting for 30% of the total volume;

[0026] Then the prepared I liquid and II liquid are mixed to make the skin penetrating agent of abamectin or ivermectin.

[0027] When in use, it is prepared according to the weight of the animal and the sensitivity of the drug to the animal, and the prepared drug is dropped into the midline of the back of the animal.

Embodiment 3

[0028] Embodiment 3 (the skin penetration agent of sulfoxide): total volume percent

[0029] Mix 40% dimethyl sulfoxide and 10% methyl salicylate to make liquid I;

[0030] Dissolve 15% of the original powder (percentage by weight) of propyl sulfoxide (purity above 60%) in ethyl acetate to prepare II liquid, accounting for 50% of the total volume;

[0031] Then mix I liquid and II liquid to make the skin penetrating agent of propyl sulfoxide.

[0032] When in use, it is prepared according to the weight of the animal and the sensitivity of the drug to the animal, and the prepared drug is dropped into the midline of the back of the animal.

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PUM

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Abstract

The animal skin penetrant is compounded with dimethyl sulfoxide and its derivative, methyl salicylate, lipid solvent, water or water buffering solution and common medicine. The transdermal medicine is absorbed through capillary vessels and conveyed to inside of the body through body circulation, and this has the advantages of no first pass effect, stable blood medicine concentration, no-pain administration, etc. The present invention can reach the same disease preventing and treating effect as oral taking and injecting, change the barrier action of the keratoderma reversibly, avoid damage to active cells, expand the permeability of medicine in skin and increase the transdermal absorption of medicine.

Description

technical field [0001] The invention relates to an animal skin penetrating agent, which is suitable for treating or preventing animal diseases. Background technique [0002] In the past, the treatment of animal infectious diseases or internal and external parasitic diseases was mostly administered orally through tablets, powders or oral liquids, or subcutaneously, intramuscularly or intravenously through injections. With the continuous development of modern pharmacy research and the in-depth study of pharmacology, leaps and bounds have been proposed in terms of drug administration routes, such as subcutaneous embedded sustained-release dosage forms, rumen drug timed release devices for ruminants, etc., all of which have proposed new drug absorption routes. ideas, or design new ideas from the mechanism of medication. [0003] Although skin care products used by human beings, anti-inflammatory agents or blood stasis agents for external use, and externa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/20A61K31/4164A61K31/4985A61K31/7048A61K47/12
Inventor 张文宝张壮志石保新吐尔洪·依米提范元良
Owner 新疆维吾尔自治区畜牧科学院兽医研究所
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