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A method for preparing houttuynia honeysuckle flower injection and product obtained thereby

A technology for extracting Houttuynia cordata and honeysuckle extract is applied in the field of preparing Houttuynia cordata extract, can solve the problems of quantitative total volatile oil, low content, poor quality of Houttuynia cordata injection, and achieves stable and reliable quality and high quality Stable and reliable results

Inactive Publication Date: 2006-12-13
厦门国宇知识产权研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the transfer rate of the volatile oil in Houttuynia cordata and honeysuckle injection prepared by the existing method and the content of main active ingredients in the volatile oil such as houttuyniatin and methyl nonanone are relatively low. For example, using the Chinese patent application "One "Preparation method and quality control method of Houttuynia cordata injection" (Application No.: 200410037630.2) In the injection prepared by the method disclosed, each 1ml injection contains only 1-20 μg of the main active ingredient methyl nonanone, and no total Quantification of volatile oil
Generally speaking, the quality of Houttuynia cordata honeysuckle injection produced by existing methods is poor, and the curative effect is unstable

Method used

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  • A method for preparing houttuynia honeysuckle flower injection and product obtained thereby
  • A method for preparing houttuynia honeysuckle flower injection and product obtained thereby

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: Preparation of Houttuynia cordata Lonicerae Injection

[0041] Take the newly harvested whole herb of Houttuynia cordata, wash and dry the surface moisture, chop it, weigh 16kg, add 128kg of water for distillation, stop the distillation when the distillate reaches 16L, and redistill the distillate, when redistilled When the liquid reaches 1.6L, stop the distillation, seal it, and store it in a refrigerator at 0-4°C to become stock solution I.

[0042] Take 8kg of newly picked honeysuckle, add 64kg of water for distillation, stop distillation when the distillate reaches 8L, collect the distillate for redistillation, stop distillation when the redistillate reaches 1.6L, and place in a refrigerator at 0-4°C Save it as stock solution II.

[0043] ① Use methyl nonanone reference substance to make 1 mg / ml (in ethyl acetate) reference substance solution and measure the content of Houttuynia cordata in stock solution I by gas chromatography. Ketone meter = 102.0...

Embodiment 2

[0046] Embodiment 2: Preparation of Houttuynia cordata Lonicerae Injection

[0047] Take the freshly harvested whole herb of Houttuynia cordata, wash it, dry the surface water, weigh 10kg of the whole herb, add 80kg of water for distillation, stop the distillation when the distillate reaches 10L, and redistill the distillate, when the weight When the distilled liquid reaches 1L, stop the distillation, seal it in a 0-4°C refrigerator and store it as stock solution I.

[0048] Take 5kg of freshly picked honeysuckle, add 50kg of water for distillation, stop the distillation when the distillate reaches 5L, and redistill the distillate, stop the distillation when the redistillate reaches 1L, and seal it in a refrigerator at 0-4°C Stored in medium, it is stock solution II.

[0049] ① Use methyl nonanone reference substance to make 1mg / ml (in ethyl acetate) reference substance solution, and measure the content of Houttuynia cordata in stock solution I according to gas chromatography...

Embodiment 3

[0052] Embodiment 3: the quality control method of Houttuynia cordata injection

[0053] Get the Houttuynia cordata injection that embodiment 1 gained carries out the content determination of volatile oil.

[0054] Determination method of volatile oil content: volatile oil determination method (Chinese Pharmacopoeia 2005 edition one appendix XD)

[0055] Precisely measure 1000ml of injection solution, put it in a 3000ml hard round bottom flask, add glass beads for a few, connect the volatile oil tester and the reflux condenser, add water from the upper end of the condenser to fill the scale part of the volatile oil tester, and when it overflows into the flask until. Put it in an electric heating mantle and heat it slowly until boiling, and keep boiling slightly for about 5 hours, until the oil volume in the measuring device does not increase any more, stop heating, leave it for a while, open the lower end piston of the measuring device, and slowly release the water until the ...

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Abstract

The invention discloses the preparing method of houttuynia cordata honeysuckle flower injection, comprising the following steps: washing the houttuynia cordata , drying it, weighing it, boiling it, and getting houttuynia cordata extract; boiling the honeysuckle flower, extracting it, and getting honeysuckle flower extract; using the houttuynia cordata extract and honeysuckle flower extract to get injection extract and injection. In the injection, the volatile oil content is lower 0.10%., the houttuyninum content is more than 24.0 mug per mg, which is calculated with C11H22O, and other components meet the fingerprint pattern specified amount.

Description

technical field [0001] The invention relates to a method for preparing Houttuynia cordata honeysuckle extract, especially Houttuynia cordata honeysuckle injection, and Houttuynia cordata honeysuckle injection prepared by the method. Background technique [0002] The fish gold preparation (made from honeysuckle and Houttuynia cordata) has a good curative effect on acute respiratory infection and acute bronchitis clinically, and is a commonly used pharmaceutical preparation for clinical and family treatment of the above diseases. Studies have shown that the volatile oil in fish gold preparations is mainly composed of houttuyfotin, cyclohexadecan-2-en-1-ol, methyl n-nonanone, 3-methylcyclohexanol, 9,12-octadecanedi enoic acid, cyclohexanone, 3-cyclohexen-1-ol, capric acid and other components, volatile oil is the main active ingredient of anti-inflammatory and bactericidal, therefore, how to maintain the transfer rate of volatile oil in the preparation process is to ensure the ...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K9/08A61P11/00
Inventor 郭东宇韩兆华袭开利
Owner 厦门国宇知识产权研究有限公司
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