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Granule for dredging cardiovascular and cerebrovascular blood vessels and method for preparing same

A technology for Naoxintong and granules, applied in the field of Naoxintong granules and their preparation, can solve the problems of affecting the speed of drug dissolution and absorption, inconvenience, difficulty in swallowing Naoxintong capsules, etc.

Inactive Publication Date: 2006-12-27
南京海辰药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the oral preparations of Naoxintong in the market include Naoxintong Capsules, which have national drug standards [WS-10001 (ZD-0001)-2002], but clinical practice shows that most patients with cerebrovascular diseases are older people , so when taking Naoxintong Capsules, it is often inconvenient due to difficulty in swallowing
In addition, the Naoxintong Capsules currently on the market are just crushed medicinal materials and then mixed and filled in proportion. After oral administration by patients, they first disintegrate into fine particles, which affects the speed of drug dissolution and absorption.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Preparation of Naoxintong main drug powder:

[0112] Astragalus 66g Radix Paeoniae Rubra 27g Danshen 27g Angelica 27g

[0113] Chuanxiong 27g, peach kernel 27g, safflower 13g, frankincense (made) 13g

[0114] Myrrh (made) 13g, Caulis Spatholobus 20g, Achyranthes bidentata 27g, Guizhi 20g

[0115] Mulberry branch 27g Dilong 27g Scorpion 13g Leech 27g

[0116] The above sixteen flavors are ground into fine powders from earthworm and scorpion; the remaining fourteen flavors such as astragalus are ground into fine powders, blended with the above powders, sieved with 80 mesh and mixed, and the main drug powder of Naoxintong is obtained.

[0117] Granule preparation

[0118] Naoxintong main medicine powder 401.0g

[0119] Sodium starch glycolate 150.0g

[0120] Carmellose Sodium 80.0g

[0121] Xanthan gum 40.0g

[0122] Lactose 310.0g

[0123] Citric acid 15.0g

[0124] Aspartame 5.0g

[0125] 10% polyvinylpyrrolidone 80% ethanol liquid solution appropriate amount ...

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PUM

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Abstract

The invention relates to medicinal granules for treating cardio-cerebrovascular diseases, wherein the raw materials include dried medicinal powder, sodium carboxymethylstarch, carmethose, xanthan gum and lactose by a predetermined proportion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a Naoxintong granule and a preparation method thereof. Background technique [0002] According to the China Cardiovascular and Cerebrovascular Prevention and Control Network: 1 / 3 of the world's people suffer from cardiovascular and cerebrovascular diseases, and 15 million people are killed by cardiovascular and cerebrovascular diseases every year, accounting for more than 3 / 5 of the death toll. China is the country with the highest incidence of cardiovascular and cerebrovascular diseases in the world. There are more than 30 million cardiovascular and cerebrovascular patients, of which 12 million are paralyzed in bed, and more than 4 million people die every year. Nowadays, with the improvement of people's life, the change of diet structure and ecological environment, the number of patients with cardiovascular and cerebrovascular diseases is increasing year...

Claims

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Application Information

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IPC IPC(8): A61K36/732A61K9/16A61P9/10A61K35/62A61K35/64A61K35/646
Inventor 曹于平蒋金元王建安郑文艳
Owner 南京海辰药业股份有限公司
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