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Dry powder preparation of chuanxiong rhizome, its preparation method and use

A technology of dry powder and preparation of Rhizoma Chuanxiong, applied in the field of dry powder preparation of Rhizoma Chuanxiong, and the field of preparation of the preparation, which can solve the problems of not finding intravenous injection drugs, etc.

Inactive Publication Date: 2006-12-27
本溪市中心医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, there is no intravenous injection drug for the treatment of cerebrovascular insufficiency and cerebrovascular infarction using a mixture of chuanxiong extract and gastrodia elata extract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Put 80Kg of Rhizoma Chuanxiong and 20Kg of Gastrodia elata into separate containers, decoct the Rhizoma Chuanxiong with 20-30 times the total weight of ethanol, the concentration used is 70%--90% ethanol, and divide 2-3 Decoct once, each decocting time is 1-2 hours, combine the decoction, and use the method of reducing pressure to recover ethanol to concentrate the decoction into extract 1; decoct with 13-20 times the total weight of gastrodia elata with ethanol Cooking, the concentration of ethanol used is 40%--70%, decocting in 2-3 times, each decocting time is 1-2 hours, combine the decoction, and then use the method of decompression recovery ethanol to shrink the decoction into Extract 2;

[0083] Utilize column chromatography to carry out column chromatography to extract 1 and extract 2 respectively, adopt NKA macroporous resin as adsorbent to Chuanxiong, and adopt water to elute first, then adopt the concentration that is 5-10 times of the weight of Chuanxiong Fo...

Embodiment 2

[0087] 40Kg of Rhizoma Chuanxiong and 60Kg of Gastrodia elata are cleaned and put into respective containers, and the active components of Dachuanxiong dry powder preparation are made according to the method of Example 1; then 50% dextran of extract total amount is added in Dachuanxiong dry powder preparation After being frozen, it is made into Dachuanxiong freeze-dried powder injection.

Embodiment 3

[0089] 50Kg of Rhizoma Chuanxiong and 50Kg of Gastrodia elata are cleaned and put into respective containers, and the active components of Dachuanxiong dry powder preparation are made according to the method of Example 1; then 50% dextran of extract total amount is added in Dachuanxiong dry powder preparation After being frozen, it is made into Dachuanxiong freeze-dried powder injection.

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Abstract

The invention relates to a powder preparation for treating or preventing cerebrovascular diseases and process for preparation, wherein the preparation is prepared from chuanxiong rhizome extract and gastrodia elata extract through the steps of ethanol grilling, reclaiming ethanol in filter liquor, concentrating, carrying out elution through column chromatography, and merging the column eluent.

Description

Technical field: [0001] The invention relates to a Dachuanxiong dry powder preparation for preventing or treating cerebrovascular diseases, a method for preparing the preparation and an application of the dry powder preparation. Background technique: [0002] The most common type of cerebrovascular disease is cerebral ischemic stroke. The clinical manifestations are headache, dizziness, tinnitus, dizziness, soreness of the waist and legs, heavy numbness of hands and feet, crooked mouth and eyes, and hemiplegia. The pathogenesis of cerebral ischemic stroke is due to stagnation of blood circulation in the brain and blockage of meridians. Arteries, resulting in ischemic stroke (ie, cerebral infarction). The traditional Chinese medicine injections currently used to treat ischemic stroke mainly include Ginadol injection (Ginkgo biloba injection) produced by Dr. Weimar Shupei Pharmaceutical Factory in Germany. This medicine mainly has the functions of scavenging free radicals, ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61K9/19A61P9/10
Inventor 周跃群黄力强周毅
Owner 本溪市中心医院
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