Reovirus inactivated vaccine and its preparation

A reovirus, inactivated vaccine technology, applied in antiviral agents, viral antigen components, inactivation/attenuation, etc., can solve the problems of unsatisfactory prevention and treatment, high price, and achieve the effect of making up for vaccine vacancies

Active Publication Date: 2007-01-17
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of foreign vaccines is not very ideal for the preventi

Method used

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[0016] The vaccine of the present invention is directed against the RS13 strain of native reovirus. The virus has no envelope and has 20-hedral symmetry. The genome is composed of 10 double-stranded RNA segments. It is resistant to heat and can tolerate 60°C for 8-10 hours. Diethyl ether is not sensitive, slightly sensitive to chloroform, sensitive to alkali, 3% sodium hydroxide can kill the virus for 1 hour, and the virus has no hemagglutinating properties.

[0017] The virus is easy to grow in chicken embryos. The yolk sac can be used for inoculation during the initial isolation. Generally, the chicken embryos die 3 to 5 days after the inoculation, and the chicken embryos are purple due to extensive subcutaneous hemorrhage. When the chorioallantoic membrane is inoculated, it usually dies in 7-8 days. The chorioallantoic membrane has slightly raised and scattered white lesions, and the chicken embryo is mildly stunted.

[0018] The virus can also multiply on chicken embryo fibrob...

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Abstract

A deactivated Avianreovirus vaccine for fowls is prepared from the Avianreovirus (ARV) RS13 (CGMCC No.1713) through separating said virus from the organ of infected chicken, serum test, reproduction of virus, deactivating, and emulsifying.

Description

Technical field [0001] The invention relates to a virus vaccine and a preparation method, specifically, a reovirus and a preparation method of the vaccine, belonging to the technical field of medical products. Background technique [0002] Avian reovirus (Avianreovirus, referred to as ARV) is one of the main pathogens of viral arthritis and tenosynovitis in chickens. It belongs to the family Reoviridae and a member of the genus Reovirus. Since Fahey and Grawly (1954) were first isolated from the respiratory tract of chickens suffering from chronic respiratory disease (ARV), many ARV isolates have been reported one after another. With the in-depth development of research, the relationship between ARV and other diseases has also attracted people's attention. It has been found that in addition to viral arthritis and tenosynovitis, ARV plays a role in the occurrence of diseases such as respiratory disease, intestinal disease, heart and liver disease, blue wing disease, broiler dwarf ...

Claims

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Application Information

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IPC IPC(8): A61K39/12A61P31/12C12N7/04
Inventor 冯秀丽厉从志
Owner TIANJIN RINGPU BIO TECH
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