Preparation of yam saponine by hydrolysis of supercritical water

A technology of diosgenin and supercritical water, which is applied in the production of steroids, bulk chemicals, organic chemistry, etc., and can solve problems such as pollution and environmental products

Inactive Publication Date: 2007-01-17
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a method of super (near) critical water hydrolysis to prepare diosgenin, to solve the environmental and finished product pollution problems caused by acid hydrolysis

Method used

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  • Preparation of yam saponine by hydrolysis of supercritical water

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Embodiment 1

[0019] Process and steps in the present embodiment are as follows:

[0020] (1) Get the average particle size of 50 meshes and mix 3 g of saponin dry powder made from 40 g of yam plant rhizome with water, and place it in a supercritical water device reactor; the weight ratio of dry powder to water is 1:50, that is, add 150 ml of water Heating in the reaction kettle to control the temperature of the supercritical water to be 250°C and the pressure to be 25MPa, so that the above-mentioned substances are hydrolyzed under the action of supercritical water;

[0021] (2) Stop heating after the hydrolysis reaction is carried out to 10 minutes, introduce the mixture in the supercritical state to condense in the coil condenser, and enter the sample collector after cooling down and depressurizing;

[0022] (3) Filter the condensed product in the collector, including the water phase and the solid phase, and retain the solid phase;

[0023] (4) Using ethanol as the extractant for the abo...

Embodiment 2

[0025] The process and steps in this embodiment are exactly the same as those in Embodiment 1 above. The difference is that 20ml of entrainer ethanol was added to the reaction kettle. Finally, 0.39 g of saponin was obtained, with a yield of 0.98% relative to the rhizome of the yam plant.

Embodiment 3

[0027] The process and steps in this embodiment are exactly the same as those in Embodiment 1 above. The difference is: the raw material put in the reaction kettle is 20g of dry root powder of yam plant, and the weight ratio with water is 1:8, that is, 160ml of water. Finally, 0.19 g of saponin was obtained, with a yield of 0.95% relative to the rhizome of the yam plant.

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Abstract

Production of diosgenin by super-critical hydrolysis is carried out by taking dioscorea plant as raw material, putting it into super-critical reactor, hydrolytic reacting at 200-300degree and 20-35MPa with water as solvent, filtering and extracting to obtain final product. It has no environmental pollution, higher purity and more yield.

Description

technical field [0001] The invention relates to a method for preparing diosgenin by super (near) critical water hydrolysis, and belongs to the technical field of extracting and refining Chinese herbal medicines. Background technique [0002] Aglycone is the precursor compound of steroid hormone drugs, chemically called Δ, 3-hydroxy, 25R spirosteroid, is the main raw material for the synthesis of steroid hormone drugs, and has important value in pharmaceutical production. Its demand in the pharmaceutical industry is also relatively large. However, saponin is difficult to synthesize by chemical methods, so the main source of the raw material is extracted from diosgenin-containing plants. [0003] Saponins contained in yams, in which saponins are connected to polysaccharides through glycoside bonds. Saponins are hydrolyzed and glycoside bonds are broken to form saponins and sugars. [0004] At present, the method for industrially producing glycosides is mainly to use inorgan...

Claims

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Application Information

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IPC IPC(8): C07J71/00C07J21/00
CPCY02P20/54
Inventor 朱宪郭晓亚王振武
Owner SHANGHAI UNIV
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