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Compositions for achieving benefits in skin using key cellular metabolic intermediates

A composition, skin technology, applied in mature, can be used to treat aging, nutritional deficiencies or areas damaged by the environment, can solve the problems of skin poisoning, obvious skin irritation, low pH, etc.

Inactive Publication Date: 2007-01-24
MARY KAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Many of the methods mentioned above to increase the rate of stratum corneum replacement have various drawbacks such as significant skin irritation, skin toxicity or low pH

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Non-limiting examples of specific KMI compositions

[0057] Table 5 below shows a non-limiting example of one embodiment of the invention. The ingredients in Table 5 were selected based on their ability to affect the content and balance of four important classes of macromolecules or hybrid molecules known to be important for the normal health and optimal function of the skin . The particular mixture of components in Table 5 is referred to as a "key metabolic intermediate" blend or KMI blend. The percentages given in Table 5 constitute a "1X" concentration of KMI blends. If the concentration of the blend is used at half the amount, the concentration of the blend is "0.5X", and if used at twice the concentration, the concentration is "2X", and so on. As will be appreciated by those skilled in the art, key metabolic components in Table 5 can be omitted and / or replaced with other components. By way of example only, sodium citrate may be replaced by potassium citrate, fr...

Embodiment 2

[0060] Materials and methods

[0061] The following procedure was used to determine the transit time of the stratum corneum in patients. Determination of stratum corneum transition time provides an indirect measure of epidermal cell activation and is a good predictor of chronic anti-aging benefits in the skin.

[0062] Up to 6 different sites on each forearm were marked using a plastic template and a baseline reading (b* value) of color intensity was determined using a Minolta colorimeter. An Occlusive Hilltop chamber (2 cm diameter) containing 0.05 ml of Mary Kay Sun Essentials(R) Sunless Tanning Lotion containing dihydroxyacetone (DHA) was placed over the site. After 6 hours, the patches were removed, and after 18 hours, the color intensity was measured again using a colorimeter. The difference between the reading and the reference was calculated as the delta b* (Δb*) value. During a guaranteed 10-day period, the panelists themselves applied the product to the brown spots...

Embodiment 3

[0071] The effect of KMI in carrier A on the cuticle turnover (Turnover) time

[0072] Table 9 below shows the effect of KMI on the Turnover Time of the stratum corneum, tested in Vehicle A. For untreated skin, the stratum corneum turnover time was estimated to be about 12.7 days, Vehicle A reduced this time to 11.2 days, an 11.7% reduction. Most, if not all, vehicles will reduce the transit time by 10-12%, and this reduction is due in part to the physical action of abrading the cuticle. Adding 1X KMI reduced the transition time by 12.8%, 2X KMI by 16.2%, and 4X KMI by 30.6%. Thus, the effect of KMI on the transition time is concentration-dependent.

[0073] deal with

[0074] *The renewal time of the stratum corneum was measured by the DHA disappearance method using a period of 10 days. Twelve panelists were included in the study and all were treated with all test formulations. Vehicle A (Table 6) is a simple non-moisturizing, non-drying oil-in-water emulsion. ...

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PUM

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Abstract

The present invention relates to novel methods and compositions comprising key metabolic ingredients for treating aged, mature, nutritionally-compromised, or environmentally-damaged skin. These methods and compositions provide improvements in the skin's visual appearance, physiological functions, clinical properties, and biophysical properties.

Description

Background of the invention [0001] A. Field of Invention [0002] The present invention generally relates to methods of treatment and compositions for improving the visual appearance, function and / or clinical / biophysical properties of the skin as a result of factors such as aging, long-term sun exposure, adverse environmental conditions and factors such as pollutants, household chemicals, disease lesions, smoking and / or malnutrition. In particular, the present invention relates to compositions and methods of use thereof, said compositions comprising a combination of naturally occurring key metabolic components that normalize abnormal metabolism in skin cells. [0003] B. Background of the Invention [0004] As a result of aging, chronic exposure to adverse environmental factors, or malnutrition, changes in the visual appearance, physical properties, and physiological functions of the skin are considered cosmetically undesirable. The most notable and noticeable changes inclu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/36A61K8/44A61K8/60A61Q1/04A61Q1/00A61Q19/00A61K9/00A61K33/42A61K33/14A61K33/00A61K31/715A61K31/70A61K31/44A61K31/38A61K31/195A61K8/20A61K8/365A61Q1/06A61Q19/08
CPCA61Q19/00A61K8/44A61Q1/06A61K8/365A61K8/20A61Q19/08A61K8/60A61K2800/70A61P17/00A61K8/30
Inventor J·R·施尔茨
Owner MARY KAY INC
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