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Medicinal composition, preparation method and quality control method

A composition and drug technology, applied in the directions of drug combination, testing drug preparation, drug formula, etc., can solve the problems of long course of treatment, low bioavailability, large side effects, etc., achieve good curative effect, easy to use and carry, and avoid adverse effects

Inactive Publication Date: 2007-02-21
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, a large number of Chinese and Western medicines have been released, but because Western medicines have no absolute advantage in cardiovascular and cerebrovascular diseases and have relatively large side effects, and Chinese medicine injections can have adverse consequences on the human body due to other impurities produced during the process of extracting active ingredients. Produced without strict quality control methods, the quality stability and safety of the obtained products are unreliable. Although the oral preparations of traditional Chinese medicines have a wide variety of options and are available, due to their low bioavailability and long course of treatment, they cannot Rapid onset of effect, so the research and development of drugs with definite curative effect, no adverse reactions, and effective control of the quality of preparations has become a new hot spot for people
In the prior art, a large number of clinical and medicinal effects have shown that ginseng or its stem and leaf parts or extracts of red ginseng and the above medicinal materials have shown unique advantages in cardiovascular and cerebrovascular diseases. Ozagrel is also aggressive in this regard. So far , and there is no report on the compatibility of the two

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: prepare ginseng extract: get 10 parts of ginseng (part is: kilogram or gram)

[0031] Ginseng medicinal material, after crushing, add 8 times the amount of 80% ethanol to soak for 4 hours, reflux extraction 3 times, 2 hours each time, combine the extracts, filter, recover the ethanol from the filtrate to a relative density of 1.05-1.10 (60°C), add water Dissolve, stand overnight, filter, extract and purify the filtrate with water-saturated n-butanol to obtain ginseng extract.

Embodiment 2

[0032] Embodiment 2: prepare red ginseng extract: 1000 parts of red ginseng (parts are: kilogram or gram)

[0033] Take the red ginseng medicinal material, add 8 times the amount of 80% ethanol to soak for 4 hours after crushing, reflux extraction 3 times, 2 hours each time, combine the extracts, filter, the relative density of ethanol recovered from the filtrate is 1.05-1.10 at 60 ° C, add water Dissolve, centrifuge at 4000r / min, centrifuge for 10min, pass the supernatant through a D301 macroporous resin column, elute with water and 10% ethanol to remove impurities, then desorb with 70% ethanol, collect the desorption liquid, recover ethanol, and dry the concentrate That is the red ginseng extract.

Embodiment 3

[0034] Embodiment 3: prepare ginseng extract: 3000 parts of ginseng (the part is: kilogram or gram)

[0035] Take ginseng medicinal materials, crush them through a 40-mesh sieve, add 8 times the amount of water to soak for 12 hours, decoct 3 times at 100°C for 2 hours, 2 hours, and 1 hour respectively, combine the extracts, and concentrate to a certain volume. The concentrated solution is purified by macroporous resin to obtain ginseng extract,

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PUM

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Abstract

A composite medicine in the form of injection or orally taken medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, apoplexy sequelae, cerebral thrombus, etc, is prepared from ginseng or its stem and leaf or red ginseng or their extract and ozagrel. Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as a preparation method and a quality control method of the composition, belonging to the technical field of medicines. technical background [0002] Cardiovascular and cerebrovascular diseases, such as coronary heart disease, myocardial infarction, and thromboembolic cerebrovascular disease are a major chronic disease that threatens the healthy population of the world, and there is a gradual upward trend in recent years. According to the report of the World Health Organization, one out of every three deaths in the world dies from cardiovascular and cerebrovascular diseases, and the mortality rate is still increasing. Cardiovascular and cerebrovascular diseases have attracted extensive attention from the medical circles at home and abroad. Therefore, it is particularly important to invent a kind of definite curative effect, safe and con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/00A61P37/04A61P9/10A61P9/12A61P7/02G01N33/15A61K31/4164
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER