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Drop pills of corydalis tuber, and preparation method

A technology of Corydalis Corydalis and dripping pills, which can be used in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve the problems of first-pass bioavailability of the liver and intestines, affect the therapeutic effect, and long dissolution time limit, etc., and achieve storage Convenient, easy to use, no dust pollution effect

Inactive Publication Date: 2007-02-21
BEIJING BORAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Corydalis is widely used in the field of traditional medicine in my country, but the oral preparations made of Corydalis single herb are mainly tablets, the product is relatively single, the dissolution time is long, slow absorption, hepatic first-pass effect and bioavailability Low degree and other problems, which affect the efficacy of the drug, but also directly affect the therapeutic effect

Method used

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  • Drop pills of corydalis tuber, and preparation method
  • Drop pills of corydalis tuber, and preparation method
  • Drop pills of corydalis tuber, and preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0042] Example 1: drug and matrix ratio test

[0043] Fix the drop distance (about 6cm), the length of the condensation column (80cm), the gradient cooling liquid (the temperature of the upper part of the temperature is 30±2°C, the temperature of the lower part of the nozzle is 10±2°C), the temperature of the oil bath is 100±5°C, and then Carry out combination test, take the smooth roundness of dropping pill as the investigation index, the results are shown in Table 1

[0044] Polyethylene glycol-4000

[0045] Calculation method of smooth and roundness rate: the dripping pills have smooth and complete appearance and high roundness as qualified products. Divide the total weight of qualified products by the total output, which is the smooth rounding rate of the sample.

[0046] It can be seen from Table 1 that under the combined conditions of using polyethylene glycol-4000 as the matrix, the mixing ratio of matrix and drug at 8:5, and the dripping temperature at 110±2...

example 2

[0051] Example 2: The way to add the drug to the matrix is ​​selected

[0052] Fixed drop distance (about 6cm), condensation column length (80cm), gradient cooling liquid (temperature at the upper part is 30+2℃, temperature at the lower part of the nozzle is 10±2℃), oil bath temperature is 100±5℃, substrate and The ratio of the drug was 8:5, the dropping temperature was 95±2°C, and the drug was added to the molten matrix in stages. The test results are shown in Table 2.

[0053] Feeding method

[0054] After the drug is added at one time, due to the large amount of drug, it is difficult to mix evenly. The appearance of the dropping pill is often rough, and the formability is not good. When the drug is added to the molten matrix in stages, it can be fully stirred. The smooth rounding rate is also high.

example 3

[0055] Example 3: Experiments with different dripper temperatures

[0056] The drug was added to the molten Matrix comparison, the test results are shown in Table 3.

[0057] Substrate: drug

[0058] When the dropping pills enter the condensate, the temperature of the coolant (20cm) is too low (20±2°C), and the prepared dropping pills often have voids or irregular pill shapes; when the temperature is too high (45±2°C), The density of the coolant here is low, the sinking speed of the prepared drop pills is too fast, and cannot be fully cooled, and flat pills or adhesions often occur; when the temperature of the coolant is controlled to 30±2°C, the roundness of the obtained drop pills is relatively high , The pill shape is smooth, therefore, the coolant should be controlled at 30±2°C.

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Abstract

A Kedaling dripping pill based on corydalis tuber for treating coronary heart disease, angina pectoris, myocardial infarction, palpitation, dizziness, etc, and its preparing process are disclosed.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, in particular to a Yanhusuo dripping pill which has the functions of promoting blood circulation and removing blood stasis, promoting qi and relieving pain, and is used for treating coronary heart disease, angina pectoris, acute myocardial infarction, chest tightness and breathlessness, palpitations and dizziness of old myocardial infarction and other diseases. and its preparation process. Background technique [0002] Corydalis is the dry tuber of Coryda [is yanhusuo] of Poppyaceae plant, which was first recorded in "Kaibao Materia Medica". Formerly known as Xuan Hu Suo, commonly known as Yuan Hu. Pungent in nature and flavor, bitter, warm, Guixin, Liver, Spleen meridian, has the effects of promoting blood circulation, promoting qi circulation, and relieving pain. Indications for qi stagnation and blood stasis pain, coronary heart disease angina pectoris and arrhythmia....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61K9/20A61P9/10A61P7/02A61K125/00
Inventor 彭丽丽单晓鹏张广林张忠斌刘志勤黄成武
Owner BEIJING BORAN PHARM CO LTD
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