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Medicinal composition, preparation method and quality control method

A composition and drug technology, applied in the directions of drug combination, testing drug preparation, drug formula, etc., to avoid disadvantages, easy to use and carry, and good curative effect.

Inactive Publication Date: 2007-02-21
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no reports of preparations that are compatible with both

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: prepare Radix Paeoniae Rubra extract: get 10 parts of Radix Radix Radix Paeoniae Alba (part is: kilogram or gram)

[0030] Take Radix Paeoniae Rubra, crush it into coarse powder, extract twice with 30% ethanol, add 10 times the amount for the first extraction for 1 hour, add 8 times the amount for the second extraction for 0.5 hours, pass the extract through the treated resin column, wash with water until sugar After the reaction is negative, 4 times column volume 40% ethanol can be eluted and adsorbed to obtain the Radix Paeoniae Rubra extract.

Embodiment 2

[0031] Embodiment 2: prepare Radix Paeoniae Rubra extract: 1000 parts of Radix Radix Radix Paeoniae Alba (kg or gram)

[0032] Take the fine powder of Radix Paeoniae Rubra, put it in a round-bottomed flask, reflux extract with 8 times the amount of 70% ethanol for 3 times, each time for 1.5 hours, filter the extract, recover it to dryness under reduced pressure, heat and dissolve the residue with an appropriate amount of water, and filter it with suction. Add the filtrate to a pre-prepared macroporous adsorption resin (the ratio of dry paste and resin is 1:15-20), after slowly adding it dropwise, first wash it with water until the reaction of reducing sugar is negative, then use 20% For ethanol elution, the initial part was collected separately, and then the 20% ethanol eluate was continuously collected, and the last part was collected separately. The 20% ethanol eluate in the middle is combined, concentrated under reduced pressure to form an extract, and dried in vacuum at lo...

Embodiment 3

[0033] Embodiment 3: prepare Radix Paeoniae Rubra extract: 3000 parts of Radix Radix Radix Paeoniae Alba (kg or gram)

[0034] Take Radix Paeoniae Rubra, crush it into coarse powder, add 13 times the amount of water to decoct 3 times, 2.5 hours each time, combine the decoction liquid, add ether for degreasing, the water layer passes through ion exchange resin to remove inorganic impurities and organic acids, and then passes through D140 macroporous resin adsorption column, using 3 times the amount of 35% ethanol as the eluent, collecting the eluent, and concentrating to obtain the Radix Paeoniae Rubra extract.

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PUM

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Abstract

A composite medicine in the form of injection or orally taken medicine for treating cardiovascular and cerebrovascular diseases, such as coronary heart disease, angina pectoris, apoplexy sequelae, cerebral thrombus, etc, is prepared from red (or white) peony root or its extract and ozagrel. Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as a preparation method and a quality control method of the composition, belonging to the technical field of medicines. technical background [0002] At present, about 4 million people die from cardiovascular and cerebrovascular diseases in my country every year, with an average of 456 deaths per hour, accounting for more than 3 / 5 of the death toll. It has become the first cause of death in China. Although drugs for the treatment of cardiovascular and cerebrovascular diseases emerge in an endless stream, the continuous changes in the spectrum of diseases make the current drugs show their limitations. Therefore, the research and development of cardiovascular and cerebrovascular diseases has always been the focus of attention. and hotspots. In the prior art, Tongmaizhi Injection (Chishao 801) obtained by modifying the structure of gallat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/00A61P9/10A61P7/02G01N33/15A61K31/4164
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER