Preparation method of metal support surface micro blind hole drug-loaded layer

A metal stent and manufacturing method technology, applied in the fields of coating, medical science, prosthesis, etc., can solve the problems of difficult to maintain the initial state, inconsistent tension, acute and subacute thrombosis in patients, etc., to increase the drug-carrying space, increase The effect of surface area

Active Publication Date: 2007-02-28
LIAONING YINYI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The drug stent is a layer of polymer drug-loaded substance adhered to the metal surface of the stent. Since the elastic modulus of the two is very different, the difference between the stent and the polymer drug-loaded layer after undergoing two plastic deformations The binding force is difficult to maintain the initial state; and because the structure of the stent is arranged at inter

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example

[0023] Example 1. Put n metal stents into 100ml 2.00mol / L NaOH solution, heat to 100C°, take out after 30min, wash with deionized water, and dry. Then immerse it in 50ml of 1.00mol / L hydrochloric acid solution, leave it for 8h, take it out, wash it with deionized water, and dry it; finally put it in an organic solution containing the drug, shake it in the microwave for 15min, take it out and dry it .

Example

[0024] Example 2. Put n metal stents into 100ml 2.00mol / L NaOH solution, heat to 100C°, take out after 30min, wash with deionized water, and dry. Then immerse it in 50ml 0.50mol / L hydrochloric acid solution, leave it for 16h, take it out, wash it with deionized water, and dry it; finally put it into an organic solution containing the drug, shake it in the microwave for 15min, take it out and dry it .

[0025] Example 3. Use n metal stents, which interact with the corrosive solution after being treated with an alkaline solution to form a relatively uniform surface of the metal stent with many blind holes with an average pore diameter of about 0.8-2.5μm; then put it into the paclitaxel solution Or CHCl for rapamycin 3 Or other volatile organic solvents, the concentration is 5mg / ml solution, after microwave vibration for 15min, take it out and dry.

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PUM

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Abstract

The invention discloses a preparing method of metal rack surface micro-blind hole drug-carrying layer, which comprises the following steps: a. heating NaOH solution at 100 deg.c to dispose metal rack surface, removing impurity and oxide film, cleaning through deionized water, drying, b. preparing 0.01-1.00mol/L etching liquid through analytical pure acid under normal temperature, marking the etching liquid, c. immersing the metal rack in the etching liquid under normal temperature for 8-20h, cleaning through deionized water, drying, d. allocating certain density of organic solution through organic solvent and metal rack carrier under normal temperature, e. placing metal rack with micro-blind hole on the surface in the organic solution under normal temperature, shocking through microwave for 15 min, drying.

Description

[0001] Field [0002] The invention relates to a method for manufacturing a drug-loaded layer through micro-blind holes, in particular to a method for manufacturing a drug-loaded layer through micro-blind holes on the surface of a metal stent. The present invention is an innovative design based on the metal stent used in the existing medical clinics. We propose to make micro-blind holes on the surface of the metal stent to serve as a drug carrier, thereby overcoming the adverse effects of the metal stent implanted in the body. Metal stents are medical biomaterials that meet the requirements of national standards, such as stainless steel for surgical implants, cobalt-chromium alloys, nickel-titanium alloys, etc. It can be applied to manufacture all cylindrical mesh stents implanted in human lumen, such as cardiovascular stents, cerebrovascular stents, peripheral vascular stents, splenic artery stents, esophageal urethral stents, etc. Background technique [0003] At present, m...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/54
Inventor 董何彦李昕跃
Owner LIAONING YINYI BIOTECH CO LTD
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