Preparation method of metal support surface micro blind hole drug-loaded layer

Abstract

The invention discloses a preparing method of metal rack surface micro-blind hole drug-carrying layer, which comprises the following steps: a. heating NaOH solution at 100 deg.c to dispose metal rack surface, removing impurity and oxide film, cleaning through deionized water, drying, b. preparing 0.01-1.00mol / L etching liquid through analytical pure acid under normal temperature, marking the etching liquid, c. immersing the metal rack in the etching liquid under normal temperature for 8-20h, cleaning through deionized water, drying, d. allocating certain density of organic solution through organic solvent and metal rack carrier under normal temperature, e. placing metal rack with micro-blind hole on the surface in the organic solution under normal temperature, shocking through microwave for 15 min, drying.

Description

[0001] Field [0002] The invention relates to a method for manufacturing a drug-loaded layer through micro-blind holes, in particular to a method for manufacturing a drug-loaded layer through micro-blind holes on the surface of a metal stent. The present invention is an innovative design based on the metal stent used in the existing medical clinics. We propose to make micro-blind holes on the surface of the metal stent to serve as a drug carrier, thereby overcoming the adverse effects of the metal stent implanted in the body. Metal stents are medical biomaterials that meet the requirements of national standards, such as stainless steel for surgical implants, cobalt-chromium alloys, nickel-titanium alloys, etc. It can be applied to manufacture all cylindrical mesh stents implanted in human lumen, such as cardiovascular stents, cerebrovascular stents, peripheral vascular stents, splenic artery stents, esophageal urethral stents, etc. Background technique [0003] At present, m...

AI Technical Summary

Problems solved by technology

[0004] The drug stent is a layer of polymer drug-loaded substance adhered to the metal surface of the stent. Since the elastic modulus of the two is very different, the difference between the stent and the polymer drug-loaded layer after undergoing two plastic deformations The binding force is difficult to maintain the initial state; and because the structure of the stent is arranged at intervals between beams, columns and bridge ribs, the tension at each point during the compression and expansion process must be inconsistent, so the interface between the drug-loaded polymer layer and the metal stent is detached to varying degrees. Occurs between the two, and the detached fragments flow into the bloodstream unequally, resulting in acute, subacute and distal thrombosis in patients