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Imiquimod turbid liquor and gelling agent thereof

An imiquimod and suspension technology is applied in the field of imiquimod gel and its preparation, which can solve the problems affecting the compliance or compliance of patients with medication, the greasy feeling of creams, and easily pollute clothes, etc., so as to achieve convenient clinical practice. Medication-free, non-greasy, smooth-looking effect

Active Publication Date: 2007-03-07
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Imiquimod cream has a definite curative effect, but because the cream has a greasy feeling, it is not easy to clean, and it is easy to contaminate clothes, which affects the compliance or compliance of patients to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Imiquimod passes through a 200-mesh sieve, takes 50 grams of imiquimod, adds 100 grams of glycerin to moisten, mixes well, then adds boric acid solution (a solution obtained by dissolving 10 grams of boric acid in 325 grams of water), and 100 grams of Absolute ethanol, stir evenly, it becomes milky white suspension liquid, obtains imiquimod suspension solution.

Embodiment 2

[0027] Take 20 grams of imiquimod, grind it into a fine powder, add 50 grams of glycerin to moisten it, and stir it evenly. Then add 120 grams of 3.5% boric acid solution and 40 grams of 95% ethanol, stir well to obtain a milky white suspension solution.

Embodiment 3

[0029] Take 10 grams of Carbomer 940, add 400 g of distilled water, and filter with gauze after the swelling is complete to obtain a translucent matrix. Add the imiquimod suspension solution obtained in Example 1 into the above-mentioned translucent matrix, stir while adding to make it evenly mixed, after stirring well, add 5 grams of triethanolamine dropwise, stir while dripping, it is milky white and opaque. gel to obtain imiquimod gel.

[0030] The pH value of the imiquimod gel obtained above is 6.89. The particle size is 10-50μm, the appearance of the product is smooth, even and fine, easy to coat. After 30 days at room temperature, the stability of the gel is good, the properties of the excipients are stable, and there is no change in compatibility with the main drug.

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Abstract

The invention relates to a climiqualine suspension and relative production, and relative medicine, as climiqualine gel. Wherein, it uses the mixture solvent of glycerin, alcohol and boracic acid solutions, to obtain stable and uniform climiqualine suspension, to make gel agent, etc.

Description

technical field [0001] The invention relates to an imiquimod suspension solution and a preparation method thereof, and a pharmaceutical preparation containing the imiquimod suspension solution, especially an imiquimod gel and a preparation method thereof. It belongs to the field of medicine. Background technique [0002] Condyloma acuminata is a sexually transmitted disease, which is caused by human papillomavirus infection. The incidence rate is second only to gonorrhea, and it is the second most common sexually transmitted disease. Currently there is no effective drug for the treatment of genital warts. The treatment methods that can be used clinically have caused great misery to patients, and the recurrence rate is extremely high. [0003] Imiquimod is an immunomodulatory drug, which belongs to the non-nucleoside isocyclic amine drugs. It has been widely used clinically for external genital and perianal condyloma acuminatum caused by human papillomavirus infection. Im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K9/00A61K31/437A61K47/02A61K47/10A61P31/12A61P15/02
Inventor 王锦刚蒋海松
Owner 北京科信聚润医药科技有限公司
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