Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Substituted quinazoline or pyridopyrimidine derivative

A kind of technology of quinazoline and pyridine, applied in the field of substituted quinazoline or pyridopyrimidine derivatives

Inactive Publication Date: 2007-03-21
BANYU PHARMA CO LTD
View PDF6 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is no specific description of the compound when the 7-position of the quinazoline skeleton is a hydrogen or fluorine atom.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Substituted quinazoline or pyridopyrimidine derivative
  • Substituted quinazoline or pyridopyrimidine derivative
  • Substituted quinazoline or pyridopyrimidine derivative

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0660] 10 parts of the compound of Example 1 described later, 15 parts of heavy magnesium oxide and 75 parts of lactose were uniformly mixed to prepare a powder or fine-grained powder of 350 μm or less. These powders are filled into capsules to make capsules.

preparation example 2

[0662] Uniformly mix 45 parts of the compound of Example 1 described later, 15 parts of starch, 16 parts of lactose, 21 parts of crystalline cellulose, 3 parts of polyvinyl alcohol and 30 parts of distilled water, then pulverize and granulate, dry, and then sieve to make a diameter It is a granule with a size of 1410-177 μm.

preparation example 3

[0664] After preparing granules by the same method as in formulation example 2, 3 parts of calcium stearate were added to 96 parts of the granules, and compression molding was performed to prepare tablets with a diameter of 10 mm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A compound having the activity of glucokinase activation and being useful for the prevention or treatment of diabetes, etc., represented by the formula: (I) [wherein X is a nitrogen atom, etc.; Y is an oxygen atom, etc.; R<1> is an optionally substituted 5 to 6-membered heteroaryl group, etc.; R<2> is a hydrogen atom or a fluorine atom; and the ring A is an optionally substituted monocyclic or bicyclic heteroaryl group of the formula: (II) ], or a pharmacologically acceptable salt thereof.

Description

technical field [0001] The present invention relates to substituted quinazoline or pyridopyrimidine derivatives. Background technique [0002] Glucokinase (GK) (ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1) is one of four mammalian hexokinase species (hexokinase IV). Hexokinase is an enzyme in the initial stage of the glycolysis system, catalyzing the reaction from glucose to glucose hexaphosphate. [0003] The expression of glucokinase is mainly limited to the liver and pancreatic β-cells, and plays an important role in the glucose metabolism of the whole body by controlling the rate phase of glucose metabolism in these cells. The glucokinase of liver and pancreatic β-cells has different sequences of 15 amino acids at the N-terminus due to different splicing, but the enzyme properties are the same. The three hexokinases (I, II, III) other than glucokinase are saturated in enzyme activity at a glucose concentration below 1 mM, and the Km of glucokinase to glucose is 8 mM...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D401/14A61K31/513A61K31/517A61K31/519A61K45/00A61P3/04A61P3/10A61P9/10A61P13/12A61P25/28A61P27/02A61P43/00C07D403/12C07D403/14C07D405/14C07D413/12C07D417/14C07D471/04C07D513/04C07D519/00C07D413/14
CPCC07D401/14C07D471/04C07D417/14C07D413/14A61K31/519C07D403/12A61K31/513C07D513/04C07D403/14C07D413/12A61K31/517A61P3/04A61P3/10A61P9/10A61P13/12A61P25/28A61P27/02A61P43/00
Inventor 三谷守弘番场诚佐佐木康裕西村辉之永木淳一荒川佳介
Owner BANYU PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com