Fusion protein for treating diabetes, and its preparing method and use

A fusion protein, diabetes technology, applied in gene therapy, chemical instruments and methods, hybrid peptides, etc., can solve the problems of dangerous sensitization of polypeptide drugs and poor efficacy of fusion proteins.
CN1935846AInactive Publication Date: 2007-03-28王庆华 +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
王庆华
Publication Date
2007-03-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to fusion protein used to prevent and cure I type and II type diabetes and its preparation method and application. It supplies the fusion protein which is formed by glucagon analogy peptide GLP-1, GLP-1 mutant and IgG-Fc, its analogy factor lizard salivary gland polypeptide extendin-4 and IgG-Fc, and the application of the above fusion protein and its DNA used in diabetes prevention and therapy. The fusion protein can increase not only GLP-1 effect, but also the affinity and immunological tolerance of ligand, which is excreted with the form of homogeneity dimmer to improve polypeptide drug effect, overcomes the defect of the GLP-1 for short half-life, and simplifies purification process.
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Description

technical field

[0001] The present invention relates to the field of biotechnology. Specifically, the present invention relates to a fusion protein for preventing and treating type I and type II diabetes, and its preparation method and application. Background technique

[0002] Diabetes is one of the main causes of human death and seriously endangers human health. Type I diabetes and type II diabetes are the two main forms of diabetes. Apoptosis, or programmed death, is the main cause of islet cell death in type I and type II diabetes. Both type I and type II diabetics exhibit progressive islet B-cell mass loss and decreased B-cell function.

[0003] Insulin therapy is the mainstay of treatment for type 1 diabetes. Pancreatic islet transplantation is also an effective treatment method, but it is restricted due to limited donors, and the recipient (patient) has to supplement immunosuppressant for life. Conventional treatment of type 2 diabetes, including diet, physical e...

Claims

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