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Liquid capsules of honeysuckle flower and coptis and preparation thereof

A technology of liquid capsules and silver yellow, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve stable quality, realize industrialization, and save preparation steps

Active Publication Date: 2010-05-12
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, each drug has its specific physical and chemical properties, and a general technical solution cannot be directly applied to the preparation of specific pharmaceutical preparations with specific physical and chemical properties without creative experimental research.

Method used

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  • Liquid capsules of honeysuckle flower and coptis and preparation thereof
  • Liquid capsules of honeysuckle flower and coptis and preparation thereof
  • Liquid capsules of honeysuckle flower and coptis and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take Scutellaria baicalensis, add boiling water to decoct twice, add 10 times the amount of water for the first decoction, add 8 times the amount of water for the second decoction, each time for 1 hour, combine the decoction liquid, filter, add sulfuric acid to the filtrate Adjust the pH value to 2, let it stand, filter the precipitate, wash it with an appropriate amount of ethanol, and dry it to obtain the Scutellaria baicalensis extract.

[0033] Take honeysuckle, add water to decoct twice, add 12 times the amount of water to the first decoction, add 10 times the amount of water to the second decoction, each time for two hours, combine the decoction liquid, filter, and add lime milk to the filtrate to adjust When the pH value reaches 10-12, let it stand still, filter and collect the precipitate, add appropriate amount of water, adjust the pH value to 6-7 with sulfuric acid, stir well, filter, and concentrate and dry the filtrate to obtain the honeysuckle extract.

[0...

Embodiment 2

[0037] Take by weighing 5 parts by weight of honeysuckle extract, 2 parts by weight of Scutellaria baicalensis extract, 67.5 parts by weight of polyethylene glycol (400), 1.5 parts by weight of polysorbate (80); prepare silvery yellow liquid according to the process described in Example 1 capsule.

Embodiment 3

[0039] Take by weighing 15 parts by weight of honeysuckle extract, 6 parts by weight of Scutellaria baicalensis extract, 45 parts by weight of polyethylene glycol (400), and 1 part by weight of polysorbate (80); prepare silvery yellow liquid according to the process described in Example 1 capsule.

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Abstract

An Yinhuang softgel is prepared through preparing its core from the extract of honeysuckle flower, the extract of scutellaria root, polyethanediol 400 and polysorbide 80 through mixing and grinding, pouring in shell, and sealing.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a silvery yellow liquid capsule and a preparation method thereof. Background technique [0002] Yinhuang preparation has the effects of clearing away heat, detoxifying and relieving sore throat. It is used for acute tonsillitis, upper respiratory tract infection and wind-heat invading the lungs resulting in fever, cough and sore throat. Yinhuang needles, tablets, granules and oral liquids made from honeysuckle and Scutellaria baicalensis extracts have all come out. [0003] However, it is inconvenient for patients to administer Yinhuang injection. At the same time, the main components of the preparation, chlorogenic acid and baicalin, will be oxidized and degraded if placed in solution for a long time. Although the tablet has a simple process and low cost, its slow disintegration and absorption will affect the curative effect; the oral liquid is inconvenient to carry ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/539A61K36/35A61P11/04
Inventor 汤旭东
Owner HAINAN HULUWA PHARMA GRP CO LTD