Compound, composition and method for preventing from neurodegeneration in injury of central nervous system

A compound and composition technology, applied in the field of neurological diseases
CN1939895AInactive Publication Date: 2007-04-04GNT PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GNT PHARMA
Publication Date
2007-04-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

A composition for preventing nervous diseases accompanied with neuron death, its method and synthesis of BAS and its derivative are disclosed. BAS and its derivative prevent cortical neuron from being damaged by N-methyl-D-aspartate, zinc ion and active oxide cluster. It can be used to treat apoplexia, cerebral traumatism, spinal injury, epilepsy and other neurodegenerative diseases, which accompany with serious neuron lost.
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Description

technical field

[0001] The present invention relates to novel salicylic acid compounds, compositions, and methods for preventing and preventing neurological diseases accompanied by neuronal death. Background technique

[0002] Excitotoxicity and Brain Disease

[0003] Hyperactivation of ionotropic glutamate receptors sensitive to N-methyl-D-aspartate (NMDA receptors) causes neuronal death and is known to mediate a variety of neurological disorders [Choi , Neuron 1:623-634 (1988)]. Glutamate is an excitatory neurotransmitter, which accumulates in large quantities in the brain and is susceptible to hypoxic-ischemic damage, which activates ionized glutamate receptors, making them accessible to calcium and sodium ions Infiltration, followed by neuronal death [Choi and Rothman, Annu Rev Neurosci: 13: 171-182 (1990)]. NMDA receptor antagonists significantly reduced hypoglycemia, hypoxia, and hypoxic-ischemia induced by brain injury [Simon, Swan, Griffiths, and Meldrum. Science...

Claims

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