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Traditional Chinese medicine composition contg. luteolin and capsule of sweeping forsythia and its prepn. method and use

A technology of luteolin and composition, applied in the field of medicine

Inactive Publication Date: 2007-04-18
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The interaction between luteolin and forsythia is now used, and the compatibility formula has not been reported yet

Method used

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  • Traditional Chinese medicine composition contg. luteolin and capsule of sweeping forsythia and its prepn. method and use
  • Traditional Chinese medicine composition contg. luteolin and capsule of sweeping forsythia and its prepn. method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0113] Example 1 Preparation of Forsythia Extract

[0114] 1. Preparation of Forsythia Crude Extract Take 1100kg of forsythia medicinal material, crush it into coarse powder, add water to decoct 3 times, add 10 times the amount of water for the first time, 8 times the amount for the second and third times, each time for 1.5 hours, combine Decoction, filter, concentrate the filtrate (50°C) under reduced pressure to a clear paste with a relative density of 1.10-1.20 (room temperature), let it cool, add 4 times the amount of ethanol, stir well, let stand for 24 hours, filter, and filtrate Ethanol was recovered under reduced pressure, and the concentrated solution was spray-dried to obtain 149.27 kg of forsythia extract, namely crude extract (for oral consumption). Among them, forsythin (C 29 h 36 o 15 ) content was 0.89%, and the yield was 13.57%.

[0115] 2. Refining of forsythia extract Take the above crude extract of forsythia, add appropriate amount of water, heat to diss...

Embodiment 2

[0118] Embodiment 2 Preparation of the composition powder injection of the present invention

[0119] prescription:

[0120] Prescription 1

[0121] Forsythia extract 130.5g (equivalent to 15kg forsythia)

[0122] Luteolin 50g

[0123] Polysorbate 80 50g

[0124] Mannitol 200g

[0125] Add sterile water for injection to 2000ml

[0126] A total of 1000 sticks were prepared

[0127] Prescription 2

[0128] Forsythia extract 261g (equivalent to 30kg forsythia)

[0129] Luteolin 50g

[0130] Polysorbate 80 50g

[0131] Mannitol 300g

[0132] Add sterile water for injection to 3000ml

[0133] A total of 1000 sticks were prepared

[0134] Prescription 3

[0135] Forsythia extract 522g (equivalent to 60kg forsythia)

[0136] Luteolin 50g

[0137] Polysorbate 80 50g

[0138] Mannitol 500g

[0139] Add sterile water for injection to 5000ml

[0140] A total of 1000 sticks were prepared

[0141] Preparation Process:

[0142] 1) First, aseptically treat the containers ...

Embodiment 3

[0152] Example 3 Preparation of the composition aqueous injection of the present invention

[0153] prescription:

[0154] Prescription 1

[0155] Forsythia extract 130.5g (equivalent to 15kg forsythia)

[0156] Luteolin 50g

[0157] Propylene glycol 500ml

[0158] Add water for injection to 2000ml

[0159] A total of 1000 sticks were prepared

[0160] Prescription 2

[0161] Forsythia extract 261g (equivalent to 30kg forsythia)

[0162] Luteolin 50g

[0163] Propylene glycol 700ml

[0164] Add water for injection to 2000ml

[0165]A total of 1000 sticks were prepared

[0166] Prescription 3

[0167] Forsythia extract 522g (equivalent to 60kg forsythia)

[0168] Luteolin 50g

[0169] Propylene glycol 900ml

[0170] Add water for injection to 2000ml

[0171] A total of 1000 sticks were prepared

[0172] Preparation Process:

[0173] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injecti...

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Abstract

A composite Chinese medicine for preventing and treating bacterial and viral diseases, inflammation and tumor, relieving pain and cough, decreasing blood fat, improving immunity, etc is proportionally prepared from luteolin and forsythia fruit or its extract. Its preparing process is also disclosed.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition prepared from luteolin, forsythia or forsythia extract, a preparation method and application thereof. 【Background technique】 [0002] Due to the current spread of resistance to many traditional antibiotics such as penicillin and amoxicillin has attracted great attention and attention from the medical community, a large number of multi-drug resistant strains and the emergence of new viruses have made refractory infections more and more serious. many. At the same time, since the compatibility of natural medicines such as traditional Chinese herbal medicines or the composition of active ingredients often have complementary and synergistic effects, and do not produce drug resistance, the discovery and research of natural medicines are increasingly valued. [0003] Luteolin (Luteolin, Lut), also known as yellow flavin, Huang Shiling, and luteolin, is a 5...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61P31/04A61K31/352
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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