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Method for preparing suspension of rhodiola root nanoliposome

A salidroside nano-liposome suspension technology, which is applied in liposome delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as high safety hazards, Achieve the effect of improving anti-fatigue and enhancing targeting

Inactive Publication Date: 2007-04-25
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this phospholipid complex is only used as a drug for injection, and a large amount of medical emulsifiers such as poloxamer and injection oil are used in the preparation, which has a large safety hazard and is not suitable for the food industry.

Method used

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  • Method for preparing suspension of rhodiola root nanoliposome

Examples

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Embodiment 1

[0015] Accurately weigh 50 g of 60-mesh Rhodiola rosea powder, pre-soak with 1450 mL of 20% (v / v) ethanol for 60 min, extract for 1 min under microwave power of 130 W and microwave irradiation time of 60 s, and filter to obtain a crude extract. The filter residue was still extracted once according to the above operation, and the crude extracts were combined twice, and concentrated to recover ethanol. The obtained crude extract of salidroside was then adsorbed by DA201-C macroporous adsorption resin, eluted with 50% (v / v) ethanol of 4 times the column volume, and the collected eluate was concentrated and recovered with ethanol and then diluted with water to red The concentration of sedroside was 1 mg / mL, and treated with an ultrafiltration membrane with a molecular weight cut-off of 3000 Da, and the collected filtrate was concentrated to dryness to prepare a phosphate buffer (pH 7.0). Accurately weigh 200mg of lecithin and 40mg of cholesterol, dissolve in 5mL of anhydrous ether...

Embodiment 2

[0017] Accurately weigh 50 g of 60-mesh Rhodiola rosea powder, pre-soak with 1250 mL of 20% (v / v) ethanol for 60 min, extract for 1 min under microwave power of 130 W and microwave irradiation time of 60 s, and filter to obtain a crude extract. The filter residue was still extracted once according to the above operation, and the crude extracts were combined twice, and concentrated to recover ethanol. The obtained crude extract of salidroside was then adsorbed by DA201-C macroporous adsorption resin, eluted with 50% (v / v) ethanol of 4 times the column volume, and the collected eluate was concentrated and recovered with ethanol and then diluted with water to red The concentration of sedroside was 1 mg / mL, and treated with an ultrafiltration membrane with a molecular weight cut-off of 3000 Da, and the collected filtrate was concentrated to dryness to prepare a phosphate buffer (pH 7.0). Accurately weigh 100mg of lecithin and 20mg of cholesterol, dissolve them in 5mL of anhydrous ...

Embodiment 3

[0019] Accurately weigh 50 g of 60-mesh Rhodiola rosea powder, pre-soak with 1500 mL of 20% (v / v) ethanol for 60 min, extract for 1 min under microwave power of 130 W and microwave irradiation time of 60 s, and filter to obtain a crude extract. The filter residue was still extracted once according to the above operation, and the crude extracts were combined twice, and concentrated to recover ethanol. The obtained crude extract of salidroside was then adsorbed by DA201-C macroporous adsorption resin, eluted with 50% (v / v) ethanol of 4 times the column volume, and the collected eluate was concentrated and recovered with ethanol and then diluted with water to red The concentration of sedroside was 1 mg / mL, and treated with an ultrafiltration membrane with a molecular weight cut-off of 3000 Da, and the collected filtrate was concentrated to dryness to prepare a phosphate buffer (pH 7.0). Accurately weigh 200mg of lecithin and 40mg of cholesterol, dissolve in 5mL of anhydrous ether...

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Abstract

The invention relates to a method for preparing gadol glycosides nanometer liposome suspension. Wherein, said suspension comprises the extractive of gadol as gadol glycosides and the nanometer liposome packing the gadol glycosides. The inventive production comprises that: dissolving the lecithin and cholesterol into absolute ether, depressurizing and vaporizing the organic solvent; adding gadol glycosides phosphate buffer with some surface activator, expanding, and dispersing at ultrasonic wave, to obtain the final suspension. The average grainness of product is lower than 100nm; the package rate of gadol glycosides can reach 25-35%.

Description

technical field [0001] The invention discloses a preparation method of salidroside nano liposome suspension, which belongs to the technical field of functional health food. Background technique [0002] Rhodiola sachalinensis A.Bor. is an oriental folk herbal medicine that has only been valued in recent decades. It is another important health-care medicinal source plant developed after ginseng and Acanthopanax. The main active ingredient is salidroside (Salidroside) and its aglycone, i.e. ρ-Tyrosol, which has a two-way regulating effect on the human body without any toxic side effects or addiction. It can promote the body's energy metabolism, Stimulate nerve excitement, regulate endocrine function and biological effects such as anti-toxin and detoxification. In recent years, many research reports have proved that salidroside has health effects such as anti-fatigue, anti-hypoxia, anti-microwave radiation, inhibition of blood sugar rise, and anti-peroxidation. Rhodiola-like ...

Claims

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Application Information

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IPC IPC(8): A61K31/7028A61K36/41A61K9/10A61K9/127A61K47/28A61P39/06A61P43/00
Inventor 许时婴张晓鸣钟芳范明辉王璋卢蓉蓉张文斌
Owner JIANGNAN UNIV
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