Pharmaceutical composition for treating disease of liver and gallbladder system and preparation and use thereof

A composition, hepatobiliary technology, applied in the direction of drug combination, medical preparations containing active ingredients, digestive system, etc., can solve problems such as inability to perform surgical treatment

Inactive Publication Date: 2007-04-25
南京宇道科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also a considerable number of patients who cannot undergo

Method used

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  • Pharmaceutical composition for treating disease of liver and gallbladder system and preparation and use thereof
  • Pharmaceutical composition for treating disease of liver and gallbladder system and preparation and use thereof
  • Pharmaceutical composition for treating disease of liver and gallbladder system and preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The preparation technology of embodiment 1 desmodium extract

[0051] Take 40kg of Desmodium herb, wash, dry and crush, add 5 times the amount of petroleum ether to reflux and degrease 3 times, each time for 1.5 hours, evaporate the medicinal materials to dry petroleum ether after degreasing; add 8 times the amount to the degreased medicinal materials 70% ethanol reflux extraction 3 times, each extraction time is 2 hours, filter, combine the three ethanol extracts, concentrate to paste, recover ethanol; add water to dissolve the concentrate, add 6 times the amount of ethyl acetate to extract, repeat Extract for 3 times, then concentrate the extract to recover ethyl acetate, vacuum-dry the concentrated extract at 60°C, and grind it into powder. Its preparation process is detailed in Figure 1 of the description.

Embodiment 2

[0052] The preparation technology of embodiment 2 gentian extract

[0053] Take 30kg of gentian, wash, dry and pulverize, add 10 times the amount of 75% ethanol to reflux and extract 3 times, each extraction time is 2 hours, filter, combine the three ethanol extracts, concentrate to a paste, and recover ethanol; Add water to dissolve the product, add 6 times the amount of ethyl acetate to extract, repeat the extraction 3 times, then concentrate the extract to recover ethyl acetate, vacuum dry the concentrated extract at 60°C, and grind it into powder. Its preparation process is detailed in Figure 2 of the description.

Embodiment 3

[0054] Example 3 Extraction process of capuchin coumarin

[0055] Wash, dry and crush 20kg of the original capillary herb, add 10, 8, and 6 times the amount of water to decoct 3 times, the extraction time is 2 hours, 1.5 hours and 1 hour respectively, combine the water extracts for three times, and concentrate under reduced pressure To relative density 1.10, the macroporous adsorption resin column (D 101 type), eluted with water until colorless, then eluted with 50%, 80%, and 90% ethanol respectively, combined the eluents, concentrated, recovered ethanol, and dried the concentrated extract under vacuum at 60°C , Grind into powder.

[0056] Its preparation process is detailed in Figure 3 of the description.

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Abstract

The invention discloses a pharmaceutical composition for treating gall stone disease and cholecystitis, which is prepared from three kinds of Chinese medicinal herbs including lysimachia christinae, rough gentian and oriental wormwood. The invention also provides the process for preparing the medicinal compound and all acceptable medicinal preparations.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine research and development, and relates to a medicinal composition and a preparation thereof for mainly treating diseases of the liver and gallbladder system, in particular to a medicinal composition composed of extracts of Chinese medicinal materials Desmodium mossium, Gentian and Capillary wormwood and its preparations. The preparation method and its preparation also relate to the medical use of the pharmaceutical composition and its preparation in the prevention and treatment of cholelithiasis, cholecystitis, hepatitis and other hepatobiliary system diseases. Background technique: [0002] Cholelithiasis and cholecystitis are the general term for acute and chronic inflammation of the biliary system and gallstone lesions. Cholelithiasis and cholecystitis often coexist at the same time, causing each other and influencing each other. Cholelithiasis, also known as cholelithiasis, refers t...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K36/51A61K36/25A61P1/16
Inventor 史美耿阮锦满姚小燕石海云彭青
Owner 南京宇道科技开发有限公司
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